Results 211 to 220 of about 87,967 (330)

Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin‐2 release from murine splenocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer [PDF]

, 1997
John E. Souness, Clare Houghton, Nughat Sardar, Michael T. Withnall   +3 more
openalex   +1 more source

Sexual function in adolescence after childhood hypospadias repair: a patient‐reported outcome study

BJU International, EarlyView.
Objective To present data on sexual function in post‐pubertal patients after hypospadias surgery in childhood. Patients and Methods We assessed 169 (96 distal, 20 midshaft, 53 proximal) patients with hypospadias born between 1991 and 2003, who underwent surgery before the age of 5 years.
Annaleena Anttila, Niklas Pakkasjärvi, Seppo Taskinen   +2 more
wiley   +1 more source

The Role of 5-Phosphodiesterase Inhibitors (PDE-5I) in Current Benign Prostatic Hyperplasia Treatment: A Narrative Review. [PDF]

Medicina (Kaunas)
Stamatiou K, Perletti G, Magri V, Trinchieri A.   +3 more
europepmc   +1 more source

Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation. [PDF]

Synapse, 2020
Heckman PRA, Roig Kuhn F, Raven F, Bolsius YG, Prickaerts J, Meerlo P, Havekes R.   +6 more
europepmc   +1 more source

Effect of cyclic AMP and phosphodiesterase inhibitors on muricide in olfactory bulbectomyzed rat

, 1987
Tatsuo Mizokawa, Kiyo Kimura, Yukihiro Ikoma, Kimio Hara, Tsuneyuki Yamamoto, Showa Ueki   +5 more
openalex   +1 more source

Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma? [PDF]

, 1996
Gordon Dent, M A Giembycz
openalex   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice. [PDF]

Nat Commun
Ajiboye J, Teixeira JE, Gasonoo M, Mattice EB, Korwin-Mihavics B, Miller P, Cameron AC, Stebbins E, Campbell SD, Griggs DW, Spangenberg T, Meyers MJ, Huston CD.   +12 more
europepmc   +1 more source

Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow. [PDF]

Korean J Ophthalmol, 2019
Kim JW, Lee JB, Lee SH.
europepmc   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source