Results 231 to 240 of about 87,967 (330)

Phosphodiesterase 4 inhibitors and db‐cAMP inhibit TNF‐α release from human mononuclear cells. Effects of cAMP and cGMP‐dependent protein kinase inhibitors [PDF]

, 1996
Aziz Hichami, Elisabeth Boichot, Nicolas Germain, E.V. Berdyshev, Olivier Coqueret, Vincent Lagente   +5 more
openalex   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Metabolic products of microorganisms. 268. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. II. Minor components belonging to the obscurolide B to D series.

, 1993
M. RITZAU, SIEGRID PHILIPPS, Axel Zeeck, HUBERT HOFF, Hans Zähner   +4 more
openalex   +2 more sources

Characterization of phosphodiesterase 4 in guinea‐pig macrophages: multiple activities, association states and sensitivity to selective inhibitors [PDF]

, 1998
John J. Kelly, Peter J. Barnes, Mark A. Giembycz   +2 more
openalex   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Effect of E1020(Phosphodiesterase inhibitor III) on hemodynamics and its blood concentration in acute congestive cardiac insuffciency.

, 1991
RINJI MURAKAMI
openalex   +2 more sources

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Effects of Various Selective Phosphodiesterase Inhibitors on Muscle Contractility in Guinea Pig Ileal Longitudinal Smooth Muscle.

, 1997
T Kaneda, Kazumasa Shimizu, Shinjiro Nakajyo, Norimoto URAKAWA   +3 more
openalex   +2 more sources

Evaluating the outcomes of pluripotent stem‐cell‐derived photoreceptor transplantation in retinal repair

The FEBS Journal, EarlyView.
Transplantation of stem cell‐derived photoreceptors in retinal repair. We summarize methods for differentiating stem cells and describe surgical techniques for transplanting photoreceptor precursors to restore visual function (A). The effectiveness of these techniques is assessed with behavioral (B) and in vitro assays (C) using mouse models that mimic
Darin Zerti, Birthe Dorgau, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako, Gerrit Hilgen   +5 more
wiley   +1 more source

The effects of caffeine and adenosine on the microbiome and lipidome of the scalp

International Journal of Cosmetic Science, EarlyView.
At 12 weeks, anti‐hair loss effects were evident with decreased Pseudomonas, Escherichia‐Shigella and Malassezia and increased Talaromyces and Cutibacterium. Lipid levels were impacted, correlating with Escherichia‐Shigella and Talaromyces. Abstract Hair loss is a complex multifactorial process.
Fengzhu Li, Shulin Liu, Zhaoying Han, Yingtian Li, Haowei Chen, Qingying Shi, Jie Tan, Xihong He, Xinyan Liu, Huabing Zhao, Fang Wang   +10 more
wiley   +1 more source