Results 21 to 30 of about 43,737 (252)

Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma [PDF]

Scientific Reports
Mitochondrial phosphoenolpyruvate carboxykinase (PCK2), a mitochondrial isoenzyme, supports the growth of cancer cells under glucose deficiency conditions in vitro.
Chenxuan Li, En-di Zhang, Youzhi Ye, Zhongyun Xiao, Hanfei Huang, Zhong Zeng   +5 more
doaj   +2 more sources

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α. [PDF]

PLoS ONE, 2017
PGC1α is a coactivator of many transcription factors and cytosolic phosphoenolpyruvate carboxykinase (PCK1) is a key enzyme for gluconeogenesis. PGC1α interacts with the transcription factor PPARγ to stimulate PCK1 expression and thus de novo glucose ...
Pedro Latorre, Luis Varona, Carmen Burgos, José A Carrodeguas, Pascual López-Buesa   +4 more
doaj   +2 more sources

Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors. [PDF]

Sci Rep, 2017
Published online: 14 September 2017Tumors frequently fail to pass on all their chromosomes correctly during cell division, and this chromosomal instability (CIN) causes irregular aneuploidy and oxidative stress in cancer cells.
Hussain R, Shaukat Z, Khan M, Saint R, Gregory SL.   +4 more
europepmc   +5 more sources

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors. [PDF]

PLoS ONE, 2016
There exist two isoforms of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in pig populations that differ in a single amino acid (Met139Leu). The isoenzymes have different kinetic properties, affecting more strongly the Km and Vmax of nucleotides.
Jorge Hidalgo, Pedro Latorre, José Alberto Carrodeguas, Adrián Velázquez-Campoy, Javier Sancho, Pascual López-Buesa   +5 more
doaj   +2 more sources

Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer [PDF]

Cancer & Metabolism, 2019
Background Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutrient availability and requirements,
Emily D. Montal, Kavita Bhalla, Ruby E. Dewi, Christian F. Ruiz, John A. Haley, Ashley E. Ropell, Chris Gordon, John D. Haley, Geoffrey D. Girnun   +8 more
doaj   +2 more sources

Correction: O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α. [PDF]

PLoS ONE, 2017
[This corrects the article DOI: 10.1371/journal.pone.0179988.].
PLOS ONE Staff
doaj   +2 more sources

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion [PDF]

Journal of Biological Chemistry, 2009
Pancreatic β-cells couple the oxidation of glucose to the secretion of insulin. Apart from the canonical KATP-dependent glucose-stimulated insulin secretion (GSIS), there are important KATP-independent mechanisms involving both anaplerosis and ...
Romana Stark, Francisco J. Pasquel, Adina F. Turcu, Rebecca L. Pongratz, Michael Roden, Gary W. Cline, Gerald I. Shulman, Richard G. Kibbey   +7 more
openalex   +2 more sources

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. [PDF]

Mol Cell, 2018
Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM.   +9 more
europepmc   +2 more sources

The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: Has it been overlooked?

Biochimica Et Biophysica Acta - General Subjects, 2014
Romana Stark
exaly   +2 more sources

Peculiarities of the relationship between the terminal site of glycolysis and the initial segment of gluconeogenesis in the myocardium and skeletal muscles of animals irradiated at different doses

Journal of Education, Health and Sport, 2023
Existing types of muscles differ not only structurally, but also metabolically (direction of energy exchange, choice of biosubstrates, dependence on the action of mediators, hormones, etc.).
G. Stepanov, R. Vastyanov, A. Kostina, E. Mokriienko   +3 more
doaj   +1 more source