Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors. [PDF]
PLoS ONE, 2016 There exist two isoforms of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in pig populations that differ in a single amino acid (Met139Leu). The isoenzymes have different kinetic properties, affecting more strongly the Km and Vmax of nucleotides.
Jorge Hidalgo +5 more
doaj +2 more sources
Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer [PDF]
Cancer & Metabolism, 2019 Background Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutrient availability and requirements,
Emily D. Montal +8 more
doaj +2 more sources
What Is the Metabolic Role of Phosphoenolpyruvate Carboxykinase?* [PDF]
Journal of Biological Chemistry, 2009 The enzyme phosphoenolpyruvate carboxykinase (GTP; EC 4.1.1.32) (PEPCK)2 has the unusual distinction of being very well studied but metabolically misunderstood.
Jianqi Yang, S. Kalhan, R. Hanson
semanticscholar +3 more sources
Correction: O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0179988.].
PLOS ONE Staff
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Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors. [PDF]
Sci Rep, 2017 Published online: 14 September 2017Tumors frequently fail to pass on all their chromosomes correctly during cell division, and this chromosomal instability (CIN) causes irregular aneuploidy and oxidative stress in cancer cells.
Hussain R +4 more
europepmc +5 more sources
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. [PDF]
Mol Cell, 2018 Latorre-Muro P +9 more
europepmc +2 more sources
The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2017 Mycobacterium tuberculosis (MTb), the causative agent of tuberculosis, can persist in macrophages for decades, maintaining its basic metabolic activities.
Iva Machová +8 more
doaj +2 more sources
Aspects of the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription* [PDF]
Journal of Biological Chemistry, 2009 This article reviews our current understanding of factors that regulate transcription of the gene for PEPCK-C, focusing on the effect of methylation on gene expression. It also provides insight into the evolutionary status of the PEPCK-C gene.
Jianqi Yang +4 more
semanticscholar +4 more sources
Nomenclature of phosphoenolpyruvate carboxykinase [PDF]
Biochemical Journal, 1987 S.K. Singla
openalex +4 more sources
The role of phosphoenolpyruvate carboxykinase in muscle alanine synthesis [PDF]
Biochemical Journal, 1984 3-Mercaptopicolinic acid (3-MPA) is reportedly a specific inhibitor of phosphoenolpyruvate (PEP) carboxykinase and has hitherto been used accordingly to elucidate the metabolic role of PEP carboxykinase in vitro and in vivo. We show that 3-MPA has multiple effects on intermediary metabolism in hemidiaphragms from 40 h-starved rats.
T. Norman Palmer +3 more
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