Results 41 to 50 of about 29,231 (198)

Effects of heterologous expression of phosphoenolpyruvate carboxykinase and phosphoenolpyruvate carboxylase on organic acid production in Aspergillus carbonarius

Journal of Industrial Microbiology & Biotechnology, 2015
Aspergillus carbonarius has a potential as a cell factory for production of various organic acids. In this study, the organic acid profile of A. carbonarius was investigated under different cultivation conditions.
Lei Yang, M. Lübeck, P. S. Lübeck
semanticscholar   +1 more source

Optimum flux rerouting for efficient production of naringenin from acetate in engineered Escherichia coli

Biotechnology for Biofuels and Bioproducts, 2022
Background Microbial production of naringenin has received much attention owing to its pharmaceutical applicability and potential as a key molecular scaffold for various flavonoids.
Dong Hwan Kim, Hyun Gyu Hwang, Gyoo Yeol Jung   +2 more
doaj   +1 more source

Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability*

Journal of Biological Chemistry, 2014
Background: The integrated stress response (ISR) is necessary to help the tumor adapt to its microenvironment. Results: ATF4 activates a PEPCK-M-dependent pro-survival pathway under amino acid deprivation or ER stress (ISR) by binding to its proximal ...
Andrés Méndez-Lucas, P. Hyroššová, Laura Novellasdemunt, F. Viñals, J. C. Perales   +4 more
semanticscholar   +1 more source

Mycobacterium tuberculosis Phosphoenolpyruvate Carboxykinase Is Regulated by Redox Mechanisms and Interaction with Thioredoxin*

Journal of Biological Chemistry, 2014
Background: Phosphoenolpyruvate carboxykinase (Pck) catalyzes the interconversion of phosphoenolpyruvate and oxaloacetate but typically prefers gluconeogenic formation of phosphoenolpyruvate.
I. Machová, J. Snášel, Michael Zimmermann, D. Laubitz, P. Płociński, W. Oehlmann, Mahavir Singh, J. Dostál, U. Sauer, I. Pichová   +9 more
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis*

Journal of Biological Chemistry, 2014
Background: PEPCK-M is generally considered irrelevant for glucose production, although gluconeogenesis has never been characterized in its absence.
R. Stark, F. Guebre-egziabher, Xiaojian Zhao, Colleen N. Feriod, Jianying Dong, T. Alves, Simona Ioja, Rebecca L. Pongratz, S. Bhanot, M. Roden, G. Cline, G. Shulman, R. Kibbey   +12 more
semanticscholar   +1 more source

Overexpression of PCK1 Gene Antagonizes Hepatocellular Carcinoma Through the Activation of Gluconeogenesis and Suppression of Glycolysis Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Gluconeogenesis, a reverse process of glycolysis, is suppressed in neoplastic livers. Cytoplasmic phosphoenolpyruvate carboxykinase (PEPCK-C/PCK1, encoded by PCK1) is a step limiting enzyme of gluconeogenesis.
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Shuqun Cheng, Wenping Zhou   +6 more
doaj   +1 more source

sRNA scr5239 Involved in Feedback Loop Regulation of Streptomyces coelicolor Central Metabolism

Frontiers in Microbiology, 2020
In contrast to transcriptional regulation, post-transcriptional regulation and the role of small non-coding RNAs (sRNAs) in streptomycetes are not well studied. Here, we focus on the highly conserved sRNA scr5239 in Streptomyces coelicolor.
Franziska Engel, Elena Ossipova, Per-Johan Jakobsson, Michael-Paul Vockenhuber, Beatrix Suess   +4 more
doaj   +1 more source

Glycolytic pyruvate kinase moonlighting activities in DNA replication initiation and elongation [PDF]

arXiv, 2020
Cells have evolved a metabolic control of DNA replication to respond to a wide range of nutritional conditions. Accumulating data suggest that this poorly understood control depends, at least in part, on Central Carbon Metabolism (CCM). In Bacillus subtilis , the glycolytic pyruvate kinase (PykA) is intricately linked to replication.
arxiv  

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source