Results 41 to 50 of about 29,850 (257)

Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions

Frontiers in Bioengineering and Biotechnology, 2021
Wild-type C. glutamicum ATCC 13032 is known to possess two enzymes with anaplerotic (C4-directed) carboxylation activity, namely phosphoenolpyruvate carboxylase (PEPCx) and pyruvate carboxylase (PCx). On the other hand, C3-directed decarboxylation can be
Jannick Kappelmann, Bianca Klein, Mathias Papenfuß, Julian Lange, Bastian Blombach, Ralf Takors, Wolfgang Wiechert, Tino Polen, Stephan Noack   +8 more
doaj   +1 more source

Minimizing acetate formation in E. coli fermentations [PDF]

, 2007
Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie, De Mey, Marjan, Soetaert, Wim, Vandamme, Erick   +3 more
core   +2 more sources

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors. [PDF]

PLoS ONE, 2016
There exist two isoforms of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in pig populations that differ in a single amino acid (Met139Leu). The isoenzymes have different kinetic properties, affecting more strongly the Km and Vmax of nucleotides.
Jorge Hidalgo, Pedro Latorre, José Alberto Carrodeguas, Adrián Velázquez-Campoy, Javier Sancho, Pascual López-Buesa   +5 more
doaj   +1 more source

Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy

Frontiers in Cell and Developmental Biology, 2023
Metabolic reprogramming is commonly accompanied by alterations in the expression of metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic reaction, but also participate in a series of molecular events to regulate tumor ...
Yong Yu, Jingying Li, Kaiming Ren
doaj   +1 more source

Combined transcriptomic-(1)H NMR metabonomic study reveals yhat monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes [PDF]

, 2011
Adipose tissue is a major storage site for lipophilic environmental contaminants. The environmental metabolic disruptor hypothesis postulates that some pollutants can promote obesity or metabolic disorders by activating nuclear receptors involved in the ...
Beale E. G., Beale E. G., Becker K., Beckonert O., Berman T., Cadoudal T., Cadoudal T., Chakravarty K., Chantal Benelli, Christianson J. L., Chui P. C., Claude Forest, Claus S. P., Cloarec O., Desvergne B., Durmaz E., Ellero S. L., Eriksson L., Eubank D. W., Feige J. N., Feige J. N., Franck Letourneur, Franckhauser S., Fukuwatari T., Gregoire F. M., Grun F., Grun F., Guan H. P., Hanson R. W., Hanson R. W., Hatch E. E., Huang da W., Huber W. W., Hurst C. H., Isabelle de Waziers, Martinelli M. I., Millward C. A., Mullerova D., Nicolas Cagnard, Okuno A., Philippe H. Beaune, Rink J. D., Roberts L. D., Roberts R. A., Sandrine Ellero-Simatos, Sandrine P. Claus, Sears D. D., Si Y., Stahlhut R. W., Su X., Targett-Adams P., Tordjman J., Trygg J., Tusher V. G., van Harmelen V., Veselkov K. A., Weuve J., Yoo H., Zancanaro C., Zhang Y. H.   +59 more
core   +2 more sources

Effect of pyruvate kinase gene deletion on the physiology of Corynebacterium glutamicum ATCC13032 under biotin-sufficient non-glutamate-producing conditions: Enhanced biomass production

Metabolic Engineering Communications, 2015
The effect of pyruvate kinase gene (pyk) deletion on the physiology of Corynebacterium glutamicum ATCC13032 was investigated under biotin-sufficient, non-glutamate-producing conditions.
Kazunori Sawada, Masaru Wada, Takuya Hagiwara, Susumu Zen-in, Keita Imai, Atsushi Yokota   +5 more
doaj   +1 more source

Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS) [PDF]

, 2010
Phosphoenolpyruvate carboxykinase-1 (PCK1) is the rate-limiting enzyme in the hepatic gluconeogenic pathway. Studies have shown that overexpression of Pck1 in mice results in obesity-related traits and higher levels of physical activity (PA).
Anders Grontved, Beale, Brage, Brito, Cao, Chang, Chang, Cole, Cole, Ekelund, Ekelund, Franckhauser, Franckhauser, Gloria-Bottini, Goodpaster, Gutin, Hakimi, Hansen, Heard-Costa, Kang, Karani S. Vimaleswaran, Kristensen, Lane, Lee, Lindgren, Ludwig, Meyre, Nicholas J. Wareham, Oberkofler, Paul W. Franks, Rajas, Rees, Riddoch, Romeo, Rosella, Ruth J.F. Loos, Sardinha, Shin, Soren Brage, Tanner, Thorleifsson, Ulf Ekelund, Vimaleswaran, Wegner, Willer, Yu   +45 more
core   +1 more source

Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells[S]

Journal of Lipid Research, 2011
Previously, we have shown that Pck1 expression in mammary gland adipocytes and white adipose tissue maintains triglyceride stores through glyceroneogenesis, and these lipids were used for synthesis of milk triglycerides during lactation.
Chang-Wen Hsieh, Charles Huang, Ilya Bederman, Jianqi Yang, Michelle Beidelschies, Maria Hatzoglou, Michelle Puchowicz, Colleen M. Croniger   +7 more
doaj   +1 more source

Changes in the microsomal proteome of tomato fruit during ripening [PDF]

, 2019
The variations in the membrane proteome of tomato fruit pericarp during ripening have been investigated by mass spectrometry-based label-free proteomics.
De Lorenzo, Giulia, Fabbri, Claudia, Licursi, Valerio, Mattei, Benedetta, Negri, Rodolfo, Pontiggia, Daniela, Spinelli, Francesco   +6 more
core   +1 more source

Chicken Liver Mitochondrial Phosphoenolpyruvate Carboxykinase [PDF]

European Journal of Biochemistry, 1970
Kinetic studies on the phosphoenolpyruvate carboxykinase (EC 4.1.1.32) catalyzed reactions (i. e. the phosphoenolpyruvate synthesis and the oxaloacetate HCO3− exchange) have been carried out with the use of a purified enzyme preparation. Intersecting initial velocity plots were obtained conforming to a sequential mechanism for both reactions ...
R A, Felicioli, R, Barsacchi, P L, Ipata
openaire   +2 more sources