Results 71 to 80 of about 26,859 (247)

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source

Glycolytic pyruvate kinase moonlighting activities in DNA replication initiation and elongation [PDF]

arXiv, 2020
Cells have evolved a metabolic control of DNA replication to respond to a wide range of nutritional conditions. Accumulating data suggest that this poorly understood control depends, at least in part, on Central Carbon Metabolism (CCM). In Bacillus subtilis , the glycolytic pyruvate kinase (PykA) is intricately linked to replication.
arxiv  

Overexpression of PCK1 Gene Antagonizes Hepatocellular Carcinoma Through the Activation of Gluconeogenesis and Suppression of Glycolysis Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Gluconeogenesis, a reverse process of glycolysis, is suppressed in neoplastic livers. Cytoplasmic phosphoenolpyruvate carboxykinase (PEPCK-C/PCK1, encoded by PCK1) is a step limiting enzyme of gluconeogenesis.
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Shuqun Cheng, Wenping Zhou   +6 more
doaj   +1 more source

sRNA scr5239 Involved in Feedback Loop Regulation of Streptomyces coelicolor Central Metabolism

Frontiers in Microbiology, 2020
In contrast to transcriptional regulation, post-transcriptional regulation and the role of small non-coding RNAs (sRNAs) in streptomycetes are not well studied. Here, we focus on the highly conserved sRNA scr5239 in Streptomyces coelicolor.
Franziska Engel, Elena Ossipova, Per-Johan Jakobsson, Michael-Paul Vockenhuber, Beatrix Suess   +4 more
doaj   +1 more source

Effects of Phosphorylation on Phosphoenolpyruvate Carboxykinase from the C4 Plant Guinea Grass [PDF]

, 2002
In the C4 plant Guinea grass (Panicum maximum), phosphoenolpyruvate carboxykinase (PEPCK) is phosphorylated in darkened leaves and dephosphorylated in illuminated leaves.
Acheson, R.M., Chen, Z., Leegood, R.C., Walker, R.P.   +3 more
core   +1 more source

Functional Characterization of Serum-Free Cultured Rat Hepatocytes for Downstream Transplantation Applications

Cell Transplantation, 2005
Although ex vivo culture of hepatocytes is known to impair functionality, it may still be considered as desirable to propagate or manipulate them in culture prior to transplantation into the host liver.
Hendryk Aurich, Sarah Koenig, Christian Schneider, Jens Walldorf, Petra Krause, Wolfgang E. Fleig, Bruno Christ   +6 more
doaj   +1 more source

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments. [PDF]

, 2015
Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism.
Aubry, J.M., Castelao, E., Choong, E., Conus, P., Delacrétaz, A., Eap, C.B., Gholamrezaee, M., Kutalik, Z., Magistretti, P., Preisig, M., Quteineh, L., Saigi-Morgui, N., Vandenberghe, F., Vollenweider, P., von Gunten, A., Waeber, G.   +15 more
core   +2 more sources

Effects of SADS‐CoV accessory proteins NS3a, NS7a, and NS7b on viral pathogenicity: A multi‐omics investigation

iMetaOmics, EarlyView.
This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan, Xiaoli Zhang, Ling Zhou, Xiaoya Zhao, Qianniu Li, Tian Lan, Jun Fu, Jingyun Ma   +7 more
wiley   +1 more source

Application of a Novel and Automated Branched DNA in Situ Hybridization Method for the Rapid and Sensitive Localization of mRNA Molecules in Plant Tissues

Applications in Plant Sciences, 2014
Premise of the study: A novel branched DNA detection technology, RNAscope in situ hybridization (ISH), originally developed for use on human clinical and animal tissues, was adapted for use in plant tissue in an attempt to overcome some of the ...
Andrew J. Bowling, Heather E. Pence, Jeffrey B. Church   +2 more
doaj   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, EarlyView.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source