Results 71 to 80 of about 28,180 (258)

Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish [PDF]

, 2015
The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study ...
Abu Hossain, Adelino V.M. Canario, Basini, Bouras, Bradford, Chakravarty, Conjard, Curthoys, De Niu, De Niu, Deborah M. Power, Deol, Ellard, Filvaroff, Gerich, Goorno, Goto, Groisillier, Guder, Haddad, Huang, Ip, Isabel Morgado, Jahn, James, Kirchner, Knox, Krebs, Krebs, Kurokawa, Law, Law, Lu, Luiz C. Kucharski, Maleque, Marsenic, Mather, McCudden, Migliorini, Mitrakou, Mommsen, Monteil, Moreau, Munoz, Nagata, Nissim, Oliveira, Oliveira, Ookata, Pedro M.G. Guerreiro, Rasmussen, Rasmussen, Roselis S.M. da Silva, Sazonova, Schein, Schmittgen, Schoolwerth, She, Stark, Stark, Stasko, Stasko, Suarez, Tamura, Taylor, Tiago Leal Martins, Tocher, Tohmiya, Turner, Van Waarde, Vanessa Schein, Varghese, Wagner, Wagner, Walton, Walton, Wang, Westberg, Wong, Yang, Yeung   +80 more
core   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zen, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class-Effect Synergy in Experimental Arthritis [PDF]

, 2013
PMCID: PMC3564948This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Grieder, Adam Al-Kashi, AE Koch, AJ Janckila, B Joe, BC Sondergaard, C Di Filippo, C Gannon, DD Brand, DH Copp, DR Mitchell, E Smith, F Buttgereit, GR Zimmermann, H Schacke, H Smolian, I MacIntyre, JA Cidlowski, JA Da Silva, JA Whitworth, James P. Gilligan, JB Smith, JJ Body, JM Stuart, John Wallace, K De Bosscher, K Henriksen, KS Kim, L Mancini, LI Plotkin, M Cochran, M Paul-Clark, M Yamaguchi, M Yamaguchi, M Yamaguchi, M Zaidi, MA Karsdal, MA Karsdal, Mauro Perretti, MF Fredin, MJ Peters, MR Edwards, N Binkley, N Mukaida, Niloufar Moradi-Bidhendi, Nozer Mehta, PJ Barnes, PJ Barnes, RA Nathan, RI Scheinman, S Aida, S van Wetering, SE Abdullahi, T Rhen, Trinidad Montero-Melendez, YH Chang   +55 more
core   +12 more sources

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability [PDF]

, 2018
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), encoded by the nuclear PCK2 gene, links TCA cycle intermediates and glycolytic pools through the conversion of mitochondrial oxaloacetate into phosphoenolpyruvate.
Hyroššová, Petra, Méndez-Lucas, Andrés, Novellasdemunt, Laura, Perales Losa, Carlos, Viñals Canals, Francesc   +4 more
core   +1 more source

D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles

Exploration, EarlyView.
In this study, Zhang and colleagues show that drinking‐water supplementation of D‐mannose serves as an effective and potential therapeutic of type 2 diabetes, with improvement of both liver health and bone mass. The effect is exerted through suppressing macrophage release of extracellular vesicles based on metabolic control of CD36 expression.
Sha Zhang, Kai Zhang, Chen‐Xi Zheng, Ying‐Feng Gao, Guo‐Rong Deng, Xu Zhang, Yuan Yuan, Ting Jia, Si‐Yuan Tang, Guang‐Xiang He, Zhen Gong, Na Zhao, Bo Ma, Hua Tian, Hong Zhang, Zhe Li, Yong‐Chang Di‐Wu, Yi‐Han Liu, Liang Kong, Jing Ma, Yan Jin, Bing‐Dong Sui   +21 more
wiley   +1 more source

Application of a Novel and Automated Branched DNA in Situ Hybridization Method for the Rapid and Sensitive Localization of mRNA Molecules in Plant Tissues

Applications in Plant Sciences, 2014
Premise of the study: A novel branched DNA detection technology, RNAscope in situ hybridization (ISH), originally developed for use on human clinical and animal tissues, was adapted for use in plant tissue in an attempt to overcome some of the ...
Andrew J. Bowling, Heather E. Pence, Jeffrey B. Church   +2 more
doaj   +1 more source

A generalized stoichiometric model of C3, C2, C2+C4, and C4 photosynthetic metabolism. [PDF]

, 2016
The goal of suppressing photorespiration in crops to maximize assimilation and yield is stimulating considerable interest among researchers looking to bioengineer carbon-concentrating mechanisms into C3 plants.
Ap Rees, Chandra Bellasio, Kotting, Laisk, Lunn, Mallmann, Stitt, Sweetlove   +7 more
core   +1 more source

Oat Bran Supplementation Improves Glucose Metabolism, Food Addiction, and Gut Microbiota in Rats With High‐Fat Diet‐Induced Obesity

Food Frontiers, EarlyView.
ABSTRACT Oat bran (OB), a byproduct of the oat milling process, is a nutrient‐dense cereal cultivated in cool, dry mountainous regions and is known for its potential health benefits. To explore its obesity‐alleviating effects and the underlying mechanisms, we examined the influence of OB on glucose metabolism, appetite‐regulating hormones, gut ...
Xue Bai, Meili Zhang, Yakun Zhang, Yuanyuan Zhang, Rui Huo, Qixin Gu, Ying Miao   +6 more
wiley   +1 more source

High energy-charged cell factory for heterologous protein synthesis [PDF]

, 2009
Overexpression of gluconeogenic phosphoenolpyruvate carboxykinase (PCK) under glycolytic conditions enables Escherichia coli to maintain a greater intracellular ATP concentration and, consequently, to up-regulate genes for amino acid and nucleotide ...
Hye Jung Kim, Pil Kim, Sang Yup Lee, Yeong Deok Kwon   +3 more
core   +1 more source

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin. [PDF]

, 2014
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Chen, Tzu-Chieh, Ching, Cecilia, Foo, Fritz, Kuo, Taiyi, McQueen, Allison, Wang, Jen-Chywan, Yan, Stephanie   +6 more
core   +1 more source