Results 121 to 130 of about 23,057 (164)

Glycine and serine inhibition of D‐glycerate dehydrogenase and 3‐phosphoglycerate dehydrogenase of rat brain

FEBS Letters, 1971
Uhr, M.L., Sneddon, M.K.
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Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase. [PDF]

Theranostics, 2018
Dong JK, Lei HM, Liang Q, Tang YB, Zhou Y, Wang Y, Zhang S, Li WB, Tong Y, Zhuang G, Zhang L, Chen HZ, Zhu L, Shen Y.   +13 more
europepmc   +1 more source

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). [PDF]

Oncotarget, 2017
Unterlass JE, Wood RJ, Baslé A, Tucker J, Cano C, Noble MME, Curtin NJ.   +6 more
europepmc   +1 more source

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. [PDF]

ACS Chem Biol, 2015
Fan J, Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD.   +7 more
europepmc   +1 more source

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells. [PDF]

Cell Death Dis, 2018
Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Lee K, Singh SK, Weaver ICG, Gujar S.   +7 more
europepmc   +1 more source

Phosphoglycerate dehydrogenase: potential therapeutic target and putative metabolic oncogene. [PDF]

J Oncol, 2014
Zogg CK.
europepmc   +1 more source

Optimization of Fermentation and Transcriptomic Analysis of a High-Protein-Producing <i>Galactomyces geotrichum</i> Strain. [PDF]

Foods
Sun L, Zhang N, Hua W, Cheng Y, Mi S, Zhou C.   +5 more
europepmc   +1 more source

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020

Expert Opinion on Therapeutic Patents, 2021
Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010.
Raphaël Frederick
exaly   +4 more sources

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Prognostic significance of phosphoglycerate dehydrogenase in breast cancer

Breast Cancer Research and Treatment, 2021
Breast cancer is the most common type of cancer affecting women worldwide. Phosphoglycerate dehydrogenase (PHGDH) is an oxidoreductase in the serine biosynthesis pathway. Although it has been reported to affect growth of various tumors, its role in breast cancer is largely unknown.
Muthukrishnan Chandrika, Pei Jou Chua, Umamaheswari Muniasamy, Ruby Yun Ju Huang, Aye Aye Thike, Cheng Teng Ng, Puay Hoon Tan, George W. Yip, Boon Huat Bay   +8 more
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Multiconformational States in Phosphoglycerate Dehydrogenase^,

Biochemistry, 2004
Phosphoglycerate dehydrogenase (PGDH) catalyzes the first step in the serine biosynthetic pathway. In lower plants and bacteria, the PGDH reaction is regulated by the end-product of the pathway, serine. The regulation occurs through a V(max) mechanism with serine binding and inhibition occurring in a cooperative manner.
Jessica K, Bell, Gregory A, Grant, Leonard J, Banaszak   +2 more
openaire   +2 more sources