Results 121 to 130 of about 170,695 (197)

Proteomics-Based RT-qPCR and Functional Analysis of 18 Genes in Metronidazole Resistance of Bacteroides fragilis

Antibiotics
Previously, we reported that metronidazole MICs are not dependent on the expression levels of nim genes in B. fragilis strains and we compared the proteomes of metronidazole-resistant laboratory B.
Bakhtiyar Mahmood, Ana Paunkov, Malgorzata Kupc, Katalin Burián, Elisabeth Nagy, David Leitsch, József Sóki   +6 more
doaj   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

3-Phosphoglycerate dehydrogenase from Corynebacterium glutamicum: the C-terminal domain is not essential for activity but is required for inhibition by L-serine.

, 2002
Peters-Wendisch P, Netzer R, Eggeling L, Sahm H. 3-Phosphoglycerate dehydrogenase from Corynebacterium glutamicum: the C-terminal domain is not essential for activity but is required for inhibition by L-serine. Applied Microbiology Biotechnology. 2002;60(
Peters-Wendisch, P., Sahm, H., Eggeling, L., Peters-Wendisch, Petra, Netzer, R.   +4 more
core   +1 more source

3-phosphoglycerate dehydrogenase as target in cancer therapy [PDF]

, 2016
PhD ThesisCancer cells adapt their metabolism to simultaneously fulfil the requirements of energy production and biomass generation necessary to sustain high proliferation rates.
Unterlass, Judith Edda.
core   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Phosphoglycerate dehydrogenase (PHGDH) [PDF]

Science-Business eXchange, 2011
openaire   +3 more sources

3-Phosphoglycerate dehydrogenase deficiency: description of two new cases in Tunisia and review of the literature.

, 2013
3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is a rare autosomal recessive disorder of serine biosynthesis. It is typically characterized by congenital microcephaly, intractable seizures of infantile onset, and severe psychomotor retardation ...
Benrhouma, Hanen, Wiame, Elsa, Turki, Ilhem, Kraoua, Ichraf, Kraoua, Lilia, Chaabouni, Habiba, Kaabachi, Naziha, Briand, Gilbert, Gouider-Khouja, Neziha, Van Schaftingen, Emile, Nasrallah, Fehmi, Rouissi, Aida   +11 more
core   +1 more source

3-phosphoglycerate dehydrogenase deficiency: a case report of a treatable cause of seizures

The Turkish Journal of Pediatrics, 2009
Serine deficiency disorders are a new group of neurometabolic diseases resulting from a deficiency in one of the three enzymes in the biosynthetic pathway of L-serine.
Turgay Coşkun, Halil Ibrahim Aydin, Mustafa Kiliç, Ali Dursun, Göknur Haliloğlu, Haluk Topaloğlu, Kader Karli-Oğuz, Tom J De Koning   +7 more
doaj  

Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions. [PDF]

Cancers (Basel), 2022
Van de Gucht M, Dufait I, Kerkhove L, Corbet C, de Mey S, Jiang H, Law KL, Gevaert T, Feron O, De Ridder M.   +9 more
europepmc   +1 more source

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

, 2017
Lower glycolysis involves a series of reversible reactions, which interconvert intermediates that also feed anabolic pathways. 3-phosphoglycerate (3-PG) is an abundant lower glycolytic intermediate that feeds serine biosynthesis via the enzyme ...
Xiaoyang Su, Boyuan Wang, Michael Haugbro, Jung-Min Kee, Tom W Muir, Wang, Boyuan, David H Perlman, Eva Ge, Su, Xiaoyang, Perlman, David H, Kang, Yibin, Joshua D Rabinowitz, Yibin Kang, Kee, Jung-Min, Mark Esposito, Ge, Eva, Esposito, Mark, Rob C Oslund, Yael David, Haugbro, Michael, Muir, Tom W, Oslund, Rob C, David, Yael, Rabinowitz, Joshua D   +23 more
core   +1 more source