Results 121 to 130 of about 182,707 (224)

Multi‐Subunit Engineering of Photorespiratory Glycine Decarboxylase Refines Photosynthesis, Growth and Metabolic Robustness of Arabidopsis

Plant, Cell &Environment, EarlyView.
ABSTRACT Photorespiration secures oxygenic photosynthesis from metabolic constraints arising from the oxygenation reaction of Rubisco in today's oxygen‐rich atmosphere. Beyond this protective function, it is vital for primary metabolism, cellular redox balance, and stomatal regulation.
Hu Sun, Yannic C. R. Wagner, Wieke‐Marie Rosenfeldt, Rhena Schumann, Stéphanie Arrivault, Guillaume Decros, Rhiannon Page, Elizabete Carmo Silva, Tracy Lawson, Wei Huang, Alisdair R. Fernie, Hermann Bauwe, Martin Hagemann, Stefan Timm   +13 more
wiley   +1 more source

Mitochondrial Respiratory Metabolism in Salt‐Stressed Barley (Hordeum vulgare): TCA Cycle Activation With Limited GABA Shunt Engagement

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants maintain energy balance under salinity stress through increased respiration and energy use, processes also associated with reactive oxygen species generation. Although respiration imposes a high energy cost, mitochondrial respiration and the tricarboxylic acid (TCA) cycle activity are vital for ATP production and for providing electron ...
Ali Bandehagh, Nicolas L. Taylor
wiley   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling

The Journal of Physiology, EarlyView.
Abstract figure legend There has been controversy about the structural (capillary) response of skeletal muscle to altered O2 status, involving decreased supply (hypoxia) or increased demand (activity). Here we demonstrate that seven days of activation of skeletal muscle by indirect electrical stimulation led to significant expansion of the capillary ...
David Hauton, Roger W.P. Kissane, James McCullagh, Stuart Egginton   +3 more
wiley   +1 more source

Crystal structures of type IIIH NAD-dependent D-3-phosphoglycerate dehydrogenase from two thermophiles

, 2014
In the l-Serine biosynthesis, D-3-phosphoglycerate dehydrogenase (PGDH) catalyzes the inter-conversion of D-3-phosphoglycerate to phosphohydroxypyruvate. PGDH belongs to 2-hydroxyacid dehydrogenases family.
Kumar, S. M., Pampa, K. J., Hemantha Kumar, G., Lokanath, N. K., Manjula, M., Kunishima, N.   +5 more
core   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Proteomics-Based RT-qPCR and Functional Analysis of 18 Genes in Metronidazole Resistance of Bacteroides fragilis

Antibiotics
Previously, we reported that metronidazole MICs are not dependent on the expression levels of nim genes in B. fragilis strains and we compared the proteomes of metronidazole-resistant laboratory B.
Bakhtiyar Mahmood, Ana Paunkov, Malgorzata Kupc, Katalin Burián, Elisabeth Nagy, David Leitsch, József Sóki   +6 more
doaj   +1 more source

Comparative proteomic analysis of bone marrow mononuclear cells and peripheral blood mononuclear cells for autologous therapeutic implantation in chronic wounds

Clinical and Translational Discovery, Volume 6, Issue 6, December 2026.
• Integrative evaluation with proteomic analysis of mononuclear cells (MNC) from bone marrow (BM) or peripheral blood (PB) sources for autologous cell implantation in patients with chronic wounds sheds light on molecular differences and clinical outcomes. • BM‐MNC and PB‐MNC exhibited distinct and source‐specific proteomic signatures.
Farina Mohamad Yusoff, Nor Azfa Johari, Masato Kajikawa, Sharifah Zakiah Syed Sulaiman, Harikrishna K R Nair, Sze‐Piaw Chin, Shinji Kishimoto, Tatsuya Maruhashi, S Fadilah S Abdul Wahid, Yukihito Higashi   +9 more
wiley   +1 more source

3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.

, 1996
Serine concentrations were markedly decreased in the cerebrospinal fluid of two brothers with congenital microcephaly, profound psychomotor retardation, hypertonia, epilepsy, growth retardation, and hypogonadism.
Carchon, H, L Van Maldergem, H Carchon, Detheux, M, E Van Schaftingen, Foulon, M, Jaeken, J, J Jaeken, M Foulon, Van Schaftingen, Emile, Van Maldergem, L, M Detheux   +11 more
core   +1 more source

Multienzyme Cascade Reactions: Compatibility, Cooperativity, and Control

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Multienzyme cascade reactions are sequences of telescoped biotransformations that avoid the isolation of intermediates and offer significant efficiency advantages over traditional multistep routes. This review article highlights recent examples of multienzyme cascades and explores how their success depends on the consideration of compatibility ...
Isabella E. E. Kroschel, Wolfgang Kroutil, Joerg H. Schrittwieser   +2 more
wiley   +1 more source