Results 131 to 140 of about 375,644 (216)

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

A Potential Role for the Interaction of Wolbachia Surface Proteins with the Brugia malayi Glycolytic Enzymes and Cytoskeleton in Maintenance of Endosymbiosis [PDF]

, 2013
The human filarial parasite Brugia malayi harbors an endosymbiotic bacterium of the genus Wolbachia. The Wolbachia represent an attractive target for the control of filarial induced disease as elimination of the bacteria affects molting, reproduction and
Bell, Aaron J., Ghedin, Elodie, Liu, Jing, Lustigman, Sara, Melnikow, Elena, O'Neill, Scott L., Unnasch, Thomas R., Xu, Shulin   +7 more
core   +3 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source

Is allostery a fuzzy concept?

FEBS Open Bio
Allostery is an important property of biological macromolecules which regulates diverse biological functions such as catalysis, signal transduction, transport, and molecular recognition.
Veronica Morea, Francesco Angelucci, Andrea Bellelli   +2 more
doaj   +1 more source

Engineering a Synthetic Formatotrophic Yeast With Enhanced Growth Capacity on Formate

Advanced Energy and Sustainability Research, Volume 7, Issue 5, May 2026.
Engineering Yeast for Growth on Formate and Methanol via Serine‐Centered C1 Coupling. By engineering serine metabolism and remodeling the rGly pathway, we rendered yeast growth strictly dependent on formate. This synthetic formatotrophy enables growth on dual‐C1 substrates by channeling formate into the central metabolism via serine deaminases and ...
Shuyuan Guo, Gulikezi Maimaitirexiati, Qiannan Zhang, Zhehao Jin, Kaidi Chen, Tiantian Zou, Xuemei Zhao, Xiangjian Liu, Zhenmin Bai, Dashuang Gao, Xudong Kong, Tao Yu   +11 more
wiley   +1 more source

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents ...
Capuani, Fabrizio, De Martino, Andrea, De Martino, Daniele, Marinari, Enzo   +3 more
core   +1 more source

Frequent and recent retrotransposition of orthologous genes plays a role in the evolution of sperm glycolytic enzymes [PDF]

, 2010
Background The central metabolic pathway of glycolysis converts glucose to pyruvate, with the net production of 2 ATP and 2 NADH per glucose molecule.
Deborah A O'Brien, Fernando Pardo-Manuel de Villena, Soumya A Vemuganti   +2 more
core   +2 more sources

Proteomic and Super‐Resolution Analyses of Murine Brown Adipocyte‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
Graphical Abstract ABSTRACT Thermogenic brown adipocytes (BAs) are not only an energy sink but also regulate systemic metabolic health through secreted factors and extracellular vesicles (EVs). Here, we investigate the baseline profiles BA‐EVs and how cold‐induced thermogenesis alters the proteome of BA‐EVs.
Menchus Quan, Yi‐Kai Liu, Maryam Mahmoodi, Muhammad Asif, Madeline Kay, Yongjie Yang, Fang Huang, Weiguo Andy Tao, Shihuan Kuang   +8 more
wiley   +1 more source