Phosphoglycerate dehydrogenase and Alzheimer’s disease [PDF]
EXCLI Journal : Experimental and Clinical SciencesEXCLI Journal; 24:Doc401; ISSN 1611 ...
Quan-Ying Liu, Shuang-Qing Zhang
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Moonlighting functions of phosphoglycerate dehydrogenase in cancer
Cell ReportsSummary: Phosphoglycerate dehydrogenase (PHGDH) is traditionally known for catalyzing the conversion of 3-phosphoglycerate (3-PG) to 3-phosphonooxypyruvate (3-PHP), a key step in the de novo synthesis of serine.
Chuanlong Wang +5 more
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Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency [PDF]
Journal of Lipid Research, 2018 Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis:
Takuya Takeichi +14 more
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Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway [PDF]
International Journal of General MedicineYuhai Zou,1,* Dongdong Li,1,* Ge Guan,1 Wenting Liu2 1Department of Cardiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, People’s Republic of China; 2Department of Otorhinolaryngology, Guangzhou First People’s ...
Zou Y, Li D, Guan G, Liu W
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Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana [PDF]
Scientific Reports, 2017 The proteinogenic amino acid l-serine is a precursor for various essential biomolecules in all organisms. 3-Phosphoglycerate dehydrogenase (PGDH) is the first committed enzyme of the phosphorylated pathway of l-serine biosynthesis, and is regulated by ...
Eiji Okamura, Masami Yokota Hirai
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Prognostic value of serum phosphoglycerate dehydrogenase and glycine levels in breast cancer [PDF]
Menopause ReviewHussam Abd Jassem, Anwar Jasib Thaaban
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Correction: Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E [PDF]
Journal of Experimental & Clinical Cancer ResearchXuhui Ma +4 more
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The Global mRNA Expression Profiles of Inhibiting PHGDH Induced Cisplatin Resistance in Gastric Cancer [PDF]
Cell Journal, 2022 Objective: Drug resistance is the main hindrance to improve the prognosis of patients with gastric cancer. Aminoacid metabolic reprograming is essential to satisfy the different requirements of cancer cells during drug resistance,of which serine ...
Kailing Pan, Xiaoya Zhao, Wenxia Xu
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Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase. [PDF]
Int J Mol Sci, 2021 The human enzyme D-3-phosphoglycerate dehydrogenase (hPHGDH) catalyzes the reversible dehydrogenation of 3-phosphoglycerate (3PG) into 3-phosphohydroxypyruvate (PHP) using the NAD+/NADH redox cofactor, the first step in the phosphorylated pathway producing L-serine.
Murtas G +4 more
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Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease. [PDF]
Protein SciAbstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Zerbini E +5 more
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