Results 21 to 30 of about 22,467 (165)
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver
Nature Communications, 2022 Chen et al. report on a renal UTX-phosphoglycerate dehydrogenase axis that regulates serine secretion to affect lipid metabolism in the kidney and liver upon over-nutrition, suggesting potential treatment targets for obesity-related diseases.
Hong Chen +15 more
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The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer. [PDF]
Int J Biol Sci, 2020 Serine, a non-essential amino acid, can be imported from the extracellular environment by transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the serine biosynthetic pathway (SSP). It has been reported that active serine synthesis might be needed for the synthesis of proteins, lipids, and nucleotides and the balance of ...
Zhao X, Fu J, Du J, Xu W.
europepmc +4 more sources
Nature Communications, 2023 The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation ...
Kui Wang +13 more
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Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Cell Reports, 2020 Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III +22 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The small-molecule inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro.
Birte Arlt +6 more
doaj +1 more source
Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
doaj +1 more source
3-phosphoglycerate dehydrogenase gene polymorphism amongst patients with thyroid gland cancer [PDF]
Medicinski Podmladak, 2016 Introduction: Thyroid gland cancer is a rare malignancy in the male population, accounting for up to 2% of all cancers, but it is the most common cancer of the endocrine system, making up to 95% of all estimated new endocrine cancer cases each year ...
Pjevalica Jelena +2 more
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Memorias do Instituto Oswaldo Cruz, 2015 Trypanosoma evansi, which causes surra, is descended from Trypanosoma brucei brucei, which causes nagana. Although both parasites are presumed to be metabolically similar, insufficient knowledge of T. evansi precludes a full comparison.
S Andrea Moreno, Mayerly Nava
doaj +1 more source
On the quaternary structure of human D-3-phosphoglycerate dehydrogenase. [PDF]
Protein SciAbstractD‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in L‐Ser metabolism have been linked to serious ...
Riva D +3 more
europepmc +4 more sources
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. [PDF]
Am J Respir Cell Mol Biol, 2018 Organ fibrosis, including idiopathic pulmonary fibrosis, is associated with significant morbidity and mortality. Because currently available therapies have limited effect, there is a need to better understand the mechanisms by which organ fibrosis occurs.
Hamanaka RB +14 more
europepmc +4 more sources