Results 261 to 268 of about 193,906 (268)

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.

Journal of Medicinal Chemistry, 2016
L. Patel, J. Chandrasekhar, Jerry B. Evarts, Kristen Forseth, Aaron C. Haran, Carmen Ip, A. Kashishian, Musong Kim, David Koditek, S. Koppenol, L. Lad, E. Lepist, M. Mcgrath, Stephane Perreault, K. Puri, A. Villaseñor, J. R. Somoza, B. Steiner, J. Therrien, J. Treiberg, G. Phillips   +20 more
semanticscholar   +1 more source

Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ.

Journal of Medicinal Chemistry, 2015
Philip N. Collier, G. Martínez-Botella, M. Cornebise, K. Cottrell, J. Doran, J. Griffith, S. Mahajan, F. Maltais, C. Moody, Emilie Porter Huck, Tiansheng Wang, A. Aronov   +11 more
semanticscholar   +1 more source

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.

Journal of Medicinal Chemistry, 2015
Kenneth Down, A. Amour, I. Baldwin, A. Cooper, A. Deakin, L. Felton, S. Guntrip, C. Hardy, Zoë A. Harrison, Kate L. Jones, P. Jones, S. Keeling, Joelle Le, S. Livia, F. Lucas, C. Lunniss, N. Parr, E. Robinson, P. Rowland, Sarah E. Smith, Daniel A. Thomas, G. Vitulli, Yoshiaki Washio, J. N. Hamblin   +23 more
semanticscholar   +1 more source

Phosphoinositide 3-Kinase-δ,γ Inhibitor for Rheumatoid Arthritis

The Journal of Pharmacology and Experimental Therapeutics, 2014
openaire   +1 more source

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

Journal of Medicinal Chemistry, 2011
Noel D'angelo, Tae-Seong Kim, K. Andrews, S. Booker, S. Caenepeel, Kui Chen, D. D'amico, Daniel J. Freeman, Jian Jiang, Longbin Liu, J. McCarter, Tisha San Miguel, E. Mullady, M. Schrag, R. Subramanian, Jin Tang, R. Wahl, Ling Wang, D. Whittington, Tian Wu, N. Xi, Yang Xu, P. Yakowec, Kevin C Yang, Leeanne P Zalameda, Nancy Zhang, P. Hughes, M. H. Norman   +27 more
semanticscholar   +1 more source

Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis.

Journal of Medicinal Chemistry, 2011
Okseon Kim, Y. Jeong, Hyunseung Lee, Sungwoo Hong, Sungwoo Hong   +4 more
semanticscholar   +1 more source

Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.

Journal of Medicinal Chemistry, 2006
V. Pomel, Jasna Klicic, David Covini, Dennis D Church, J. Shaw, K. Roulin, Fabienne Burgat-Charvillon, Delphine Valognes, M. Camps, C. Chabert, C. Gillieron, B. Françon, D. Perrin, D. Leroy, D. Gretener, A. Nichols, P. Vitte, S. Carboni, C. Rommel, M. Schwarz, T. Rückle   +20 more
semanticscholar   +1 more source

Phosphoinositide 3-kinase pathway inhibitors: pharmacology, metabolism & drug development.

Current medicinal chemistry, 2011
openaire   +2 more sources