Results 161 to 170 of about 425,150 (316)

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

Journal of Allergy and Clinical Immunology, 2017
T. Coulter, Anita Chandra, C. Bacon, J. Babar, J. Curtis, N. Screaton, J. Goodlad, George Farmer, C. Steele, T. Leahy, R. Doffinger, H. Baxendale, J. Bernatoniene, David Edgar, H. Longhurst, S. Ehl, C. Speckmann, B. Grimbacher, A. Šedivá, T. Milota, S. Faust, Anthony P. Williams, G. Hayman, Z. Kucuk, Rosie Hague, P. French, R. Brooker, Peter Forsyth, R. Herriot, C. Cancrini, P. Palma, P. Ariganello, N. Conlon, C. Feighery, P. Gavin, A. Jones, K. Imai, M. Ibrahim, Gašper Markelj, M. Abinun, F. Rieux-Laucat, Sylvain Latour, Isabelle Pellier, Alain Fischer, F. Touzot, J. Casanova, A. Durandy, Siobhan O. Burns, S. Savic, D. S. Kumararatne, D. Moshous, S. Kracker, Bart Vanhaesebroeck, Klaus Okkenhaug, C. Picard, S. Nejentsev, Alison M. Condliffe, Andrew J. Cant   +57 more
semanticscholar   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo

Nano Select, EarlyView.
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng, Yi Yu, Mingyi Chen, Weibin Wu, Chunyan Zhu, Caisheng Wu, Weihua Li, Zehua Liu, Qiang Xie   +8 more
wiley   +1 more source

Proteopedia entry: Phosphoinositide 3‐kinase [PDF]

Biochemistry and Molecular Biology Education, 2011
openaire   +2 more sources

Phosphoinositide 3‐Kinase in Asthma: Novel Roles and Therapeutic Approaches

American Journal of Respiratory Cell and Molecular Biology, 2017
Edwin J. Yoo, C. Ojiaku, Krishna Sunder, R. Panettieri   +3 more
semanticscholar   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.

Biochemical Journal, 2016
J. Backer
semanticscholar   +1 more source

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

Cell, 2016
Hai Hu, Ashish Juvekar, C. Lyssiotis, Evan C Lien, J. Albeck, Doogie Oh, G. Varma, Y. P. Hung, Soumya Ullas, Josh Lauring, Pankaj Seth, Mark Lundquist, D. Tolan, Aaron K. Grant, Daniel J. Needleman, J. Asara, L. Cantley, G. Wulf   +17 more
semanticscholar   +1 more source