Results 11 to 20 of about 425,150 (316)

Phenotype of ARDS alveolar and blood neutrophils [PDF]

American Journal of Respiratory and Critical Care Medicine, 2016
RATIONALE: Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied ...
Alison Condliffe, Augustin Amour, Benjamini Y, Charlotte Summers, Daniel M. L. Storisteanu, David House, Edith M. Hessel, Edwin R. Chilvers, Glyn Bradley, Gosselin EJ, Hamers L, Jatinder K. Juss, Jurgen Herre, Kim Hoenderdos, Ley K, Malcolm Begg, Mark Lennon, Mascellino MT, McColl SR, Weiland JE, Yamamoto K   +20 more
core   +3 more sources

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Journal of Neuroinflammation, 2021
Microglia are integral mediators of innate immunity within the mammalian central nervous system. Typical microglial responses are transient, intending to restore homeostasis by orchestrating the removal of pathogens and debris and the regeneration of ...
Erskine Chu, Richelle Mychasiuk, Margaret L. Hibbs, Bridgette D. Semple   +3 more
doaj   +2 more sources

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry

Frontiers in Immunology, 2018
Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous primary immunodeficiency.
Maria Elena Maccari, Maria Elena Maccari, Hassan Abolhassani, Hassan Abolhassani, Asghar Aghamohammadi, Alessandro Aiuti, Olga Aleinikova, Catherine Bangs, Safa Baris, Federica Barzaghi, Helen Baxendale, Matthew Buckland, Siobhan O. Burns, Caterina Cancrini, Caterina Cancrini, Andrew Cant, Pascal Cathébras, Marina Cavazzana, Marina Cavazzana, Marina Cavazzana, Anita Chandra, Anita Chandra, Francesca Conti, Francesca Conti, Tanya Coulter, Lisa A. Devlin, J. David M. Edgar, Saul Faust, Alain Fischer, Alain Fischer, Alain Fischer, Marina Garcia Prat, Lennart Hammarström, Maximilian Heeg, Maximilian Heeg, Stephen Jolles, Elif Karakoc-Aydiner, Gerhard Kindle, Ayca Kiykim, Dinakantha Kumararatne, Bodo Grimbacher, Hilary Longhurst, Nizar Mahlaoui, Nizar Mahlaoui, Tomas Milota, Fernando Moreira, Despina Moshous, Despina Moshous, Despina Moshous, Anna Mukhina, Olaf Neth, Benedicte Neven, Benedicte Neven, Benedicte Neven, Alexandra Nieters, Peter Olbrich, Ahmet Ozen, Jana Pachlopnik Schmid, Capucine Picard, Capucine Picard, Seraina Prader, William Rae, Janine Reichenbach, Stephan Rusch, Sinisa Savic, Alessia Scarselli, Alessia Scarselli, Raphael Scheible, Anna Sediva, Svetlana O. Sharapova, Anna Shcherbina, Mary Slatter, Pere Soler-Palacin, Aurelie Stanislas, Felipe Suarez, Francesca Tucci, Annette Uhlmann, Joris van Montfrans, Klaus Warnatz, Anthony Peter Williams, Phil Wood, Sven Kracker, Sven Kracker, Alison Mary Condliffe, Stephan Ehl, Stephan Ehl   +85 more
doaj   +2 more sources

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

Frontiers in Oncology, 2018
Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant regulation of oncogenic signaling cascades such as the phosphoinositide 3 ...
Nikos Koundouros, Nikos Koundouros, George Poulogiannis, George Poulogiannis   +3 more
doaj   +2 more sources

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease

Frontiers in Pharmacology, 2015
Class I phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases activated by cell membrane receptors, either receptor tyrosine kinases (RTKs) or G protein-coupled receptors (GPCRs), to catalyze the production of the lipid second messenger ...
Alessandra eGhigo, Mingchuan eLi
doaj   +2 more sources

Phosphoinositide 3-kinase inhibitors in lymphoma [PDF]

Current Opinion in Oncology, 2014
The phosphoinositide 3-kinase (PI3K) pathway, with downstream targets including Akt and mammalian target of rapamycin, has been implicated in numerous human cancers, including hematologic malignancies and lymphomas. The development and refinement of PI3K inhibitors directed toward this pathway show promising clinical efficacy.
Emily, Curran, Sonali M, Smith
openaire   +3 more sources

Phosphoinositide 3-Kinase Signaling in the Tumor Microenvironment: What Do We Need to Consider When Treating Chronic Lymphocytic Leukemia With PI3K Inhibitors?

Frontiers in Immunology, 2021
Phosphoinositide 3-kinases (PI3Ks) and their downstream proteins constitute a signaling pathway that is involved in both normal cell growth and malignant transformation of cells.
Ebru Aydin, Ebru Aydin, Sebastian Faehling, Sebastian Faehling, Mariam Saleh, Mariam Saleh, Laura Llaó Cid, Laura Llaó Cid, Martina Seiffert, Philipp M. Roessner   +9 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Catapano, AL, Chiozzotto, D, Falasca, M, Maffucci, T, Mavrommati, I, Norata, GD, Pineiro, R, Tibolla, G, Wheeler, AP   +8 more
core   +12 more sources

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection

Viruses, 2020
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark, Gretchen V. Gee, Brandon S. Albright, Benedetta Assetta, Ying Han, Walter J. Atwood, Daniel DiMaio   +6 more
doaj   +1 more source