Results 21 to 30 of about 18,679,675 (294)
Haematologica, 2012 Juvenile myelomonocytic leukemia is a lethal disease of children characterized by hypersensitivity of hematopoietic progenitors to granulocyte macrophage-colony stimulating factor.
Charles B. Goodwin +4 more
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Targeting Phosphoinositide 3-Kinase – Five Decades of Chemical Space Exploration
CHIMIA, 2021 Phosphoinositide 3-kinase (PI3K) takes a key role in a plethora of physiologic processes and controls cell growth, metabolism, immunity, cardiovascular and neurological function, and more.
Chiara Borsari, Matthias P. Wymann
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Phosphoinositide 3-kinase p85beta regulates invadopodium formation
Biology Open, 2014 The acquisition of invasiveness is characteristic of tumor progression. Numerous genetic changes are associated with metastasis, but the mechanism by which a cell becomes invasive remains unclear.
Ariel E. Cariaga-Martínez +8 more
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Phosphoinositide 3-kinase p110γ in immunity [PDF]
IUBMB Life, 2011 The rapid and accurate response of leukocytes to environmental cues is critical for a proper inflammatory reaction to foreign particles or invading microbes. In the last decade, the signal transduction enzyme phosphoinositide 3-kinase γ (PI3Kγ) has emerged as a critical modulator of leukocyte responses, with its effects spanning from recruitment to the
COSTA, Carlotta +2 more
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Phosphoinositide 3-kinase signaling in the vertebrate retina
Journal of Lipid Research, 2010 The phosphoinositide (PI) cycle, discovered over 50 years ago by Mabel and Lowell Hokin, describes a series of biochemical reactions that occur on the inner leaflet of the plasma membrane of cells in response to receptor activation by extracellular ...
Raju V.S Rajala
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FEBS Open Bio, 2020 Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
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Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]
, 2010 The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
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Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]
, 2005 Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
S. Jayasekera +11 more
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Frontiers in Pediatrics, 2018 Activated phosphoionositide-3 kinase delta syndrome (APDS) is a rare disorder caused by activating mutations in phosphoionositide 3-kinase delta (PI3Kδ).
Michele N. Pham +2 more
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PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
Clinical and Translational Medicine, 2020 Background Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivity in chronic airway diseases ...
Jing Bi +10 more
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