Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies [PDF]
Haematologica, 2014 The phosphoinositide 3-kinase pathway represents an important anticancer target because it has been implicated in cancer cell growth, survival, and motility. Recent studies show that PI3K may also play a role in the development of resistance to currently
Elias Jabbour +3 more
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Cancer Management and Research, 2013 Chanse Fyffe, Marco Falasca Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signallling Group, London, UK Abstract: It should be noted that 3-phosphoinositide-dependent protein kinase-1
Fyffe C, Falasca M
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Proteomic investigation of the class IA phosphoinositide 3-kinase signalling pathway [PDF]
, 2012 PhDClass IA phosphoinositide 3-kinases (PI3Ks) are a family of enzymes with key roles in the regulation of signalling pathways, many of which are mediated through Akt.
Beltran, Luisa
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Immunodeficiency due to a novel variant in PIK3CD: a case report
Pediatric Rheumatology Online Journal, 2023 Background Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to mutations in the phosphoinositide ...
Niloofar Shashaani +6 more
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Frontiers in Immunology, 2021 Phosphoinositide 3-kinases (PI3Ks) and their downstream proteins constitute a signaling pathway that is involved in both normal cell growth and malignant transformation of cells.
Ebru Aydin +9 more
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Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection
Viruses, 2020 Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark +6 more
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Effect of CHKA gene silencing on biological behavior of glioma cell and its mechanism [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Glioma is one of the common intracranial malignant tumors, but the specific mechanism was unclear. The expression level of choline kinase A (CHKA) is positively correlated with the malignant grade of glioma.
HUANG Ling , ZOU Yourui , LI Zuoqi , MA Yue , GAO Xinyi , MA Hui
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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]
, 2014 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Ward, Richard +10 more
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Vps34 is a phosphatidylinositol 3-kinase, not a phosphoinositide 3-kinase [PDF]
Autophagy, 2011 There seems to be some confusion regarding the naming of enzymes that phosphorylate certain lipids. In particular, we are referring to the lipid phosphatidylinositol and to phosphoinositides. Inositides are inositol-containing derivatives of phosphatidic acid (Fig. 1).
Meijer, A.J., Klionsky, D.J.
openaire +4 more sources
A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]
, 2009 Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania +40 more
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