Results 191 to 200 of about 425,150 (316)

Identification of novel FGFR2::TXLNB Fusion in a polymorphous low‐grade neuroepithelial tumor of the young

Brain Pathology, EarlyView.
We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu, Tian‐Yuan Tan, Wei Yan, Bo Wang   +3 more
wiley   +1 more source

Overall survival among patients with activated phosphoinositide 3-kinase delta syndrome (APDS). [PDF]

Orphanet J Rare Dis
Mahendran M, Upton JEM, Ramasubramanian R, Memmott HL, Germain G, Büsch K, Laliberté F, Harrington A.   +7 more
europepmc   +1 more source

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Science, 2013
I. Angulo, O. Vadas, F. Garçon, E. Banham-Hall, V. Plagnol, T. Leahy, H. Baxendale, T. Coulter, J. Curtis, Changxing Wu, K. Blake-Palmer, O. Perisic, D. Smyth, Mailis Maes, C. Fiddler, J. Juss, D. Cilliers, Gašper Markelj, Anita Chandra, George Farmer, Anna Kielkowska, J. Clark, S. Kracker, M. Debré, C. Picard, I. Pellier, N. Jabado, James A. Morris, G. Barcenas-Morales, A. Fischer, L. Stephens, P. Hawkins, J. Barrett, M. Abinun, M. Clatworthy, A. Durandy, R. Doffinger, E. Chilvers, A. Cant, D. Kumararatne, K. Okkenhaug, Roger L. Williams, Alison M. Condliffe, S. Nejentsev   +43 more
semanticscholar   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

The Importance of Phosphoinositide 3-Kinase in Neuroinflammation. [PDF]

Int J Mol Sci
Wright B, King S, Suphioglu C.
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome. [PDF]

Clin Exp Med
Hartog NL, Wu EY, Rider NL, Meng Y, Hartline B, Adams P, Aggarwal S, Harrington A.   +7 more
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Phosphoinositide 3-kinase-γ (PI3Kγ) [PDF]

Science-Business eXchange, 2011
  +5 more sources

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.

Biochemical Journal, 1998
P. Shepherd, D. Withers, K. Siddle
semanticscholar   +1 more source