Results 181 to 190 of about 11,249 (206)

Mammalian phosphoinositide kinases and phosphatases

Progress in Lipid Research, 2009
Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and internal membranes and play pivotal roles in the regulation of a wide variety of cellular processes. Phosphoinositides are molecularly diverse due to variable phosphorylation of the hydroxyl groups of their inositol rings.
Takehiko, Sasaki, Shunsuke, Takasuga, Junko, Sasaki, Satoshi, Kofuji, Satoshi, Eguchi, Masakazu, Yamazaki, Akira, Suzuki   +6 more
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TPIP: a novel phosphoinositide 3-phosphatase

Biochemical Journal, 2001
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] 3-phosphatase that plays a critical role in regulating many cellular processes by antagonizing the phosphoinositide 3-kinase signalling pathway.
Walker, Steven, Downes, Pete, Leslie, Nicholas   +2 more
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PTEN and Myotubularin: Novel Phosphoinositide Phosphatases

Annual Review of Biochemistry, 2001
▪ Abstract  Protein tyrosine phosphatases (PTPs) are a diverse group of enzymes that contain a highly conserved active site motif, Cys-x5-Arg (Cx5R). The PTP super-family enzymes, which include tyrosine-specific, dual specificity, low-molecular-weight, and Cdc25 phosphatases, are key mediators of a wide variety of cellular processes, including growth,
T, Maehama, G S, Taylor, J E, Dixon
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Myotubularin phosphatases: policing 3-phosphoinositides

Trends in Cell Biology, 2006
In eukaryotic cells, phosphatidylinositol is subject to differential phosphorylation, resulting in the production of seven distinct phosphatidylinositol phosphates, often referred to as phosphoinositides (PIs). PIs have numerous distinct roles in cellular regulation and membrane trafficking.
Fred L, Robinson, Jack E, Dixon
openaire   +2 more sources

ChemInform Abstract: Phosphoinositide‐Regulated Kinases and Phosphoinositide Phosphatases

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nick R. Leslie, Ricardo M. Biondi, Dario R. Alessi   +2 more
openaire   +1 more source

Phosphoinositide Phosphatases: Emerging Roles As Voltage Sensors?

Molecular Interventions, 2005
During a genomic survey of the transparent sea squirt (Ciona intestinalis), Murata et al. discovered a gene that encodes a protein containing homologous sequences to both a CX(5)R phosphatase and an ion channel. The authors named the novel protein, C. intestinalis voltage-sensor-containing phosphatase, Ci-VSP.
Carolyn A, Worby, Jack E, Dixon
openaire   +2 more sources

Regulating GLUT4 vesicle dynamics by phosphoinositide kinases and phosphoinositide phosphatases

Frontiers in Bioscience, 2003
Phosphorylated derivatives of phosphatydylinositol (PtdIns), collectively called phosphoinositides (PIs), have been recognized as versatile second messengers and modulators of lipid membrane composition in all eukaryotes. Over the last several years, PIs emerged as key membrane-localized signals for regulating a myriad of cellular processes, including ...
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PTEN and Myotubularins: Families of Phosphoinositide Phosphatases

2003
Publisher Summary This chapter discusses PTEN and Mytobularins, families of Phosphoinositides phosphatases, playing crucial roles in a variety of complex cellular processes. The involvement of phosphoinositides in such a striking number of physiologic processes has led to intensive study of the protein effectors, including lipid kinases and ...
Gregory S, Taylor, Jack E, Dixon
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Myotubularin Phosphoinositide Phosphatases in Human Diseases

2012
The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the amino acid signature Cys-X5-Arg-Thr ...
Amoasii, Leonela, Hnia, Karim, Laporte, Jocelyn   +2 more
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Assaying Inositol and Phosphoinositide Phosphatase Enzymes

2013
One critical aspect of phosphoinositide signaling is the turnover of signaling molecules in the pathway. These signaling molecules include the phosphatidylinositol phosphates (PtdInsPs) and inositol phosphates (InsPs). The enzymes that catalyze the breakdown of these molecules are thus important potential regulators of signaling, and in many cases the ...
Janet L, Donahue, Mustafa, Ercetin, Glenda E, Gillaspy   +2 more
openaire   +2 more sources