Results 191 to 200 of about 11,249 (206)
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Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularin
Cellular and Molecular Life Sciences (CMLS), 2003Phosphoinositides play a central role in the control of major eukaryotic cell signaling mechanisms. Accordingly, the list of phosphoinositide-metabolizing enzymes implicated in human diseases has considerably increased these last years. Here we will focus on myotubularin, the protein mutated in the X-linked myotubular myopathy (XLMTM) and the founding ...
Tronchere, Helene +3 more
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Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
Nature, 2005Changes in membrane potential affect ion channels and transporters, which then alter intracellular chemical conditions. Other signalling pathways coupled to membrane potential have been suggested but their underlying mechanisms are unknown. Here we describe a novel protein from the ascidian Ciona intestinalis that has a transmembrane voltage-sensing ...
Yoshimichi, Murata +4 more
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The Sac1 phosphoinositide phosphatases in mammals
2009Phosphoinositides (PIPs) are ubiquitous regulators of signal transduction events in eukaryotic cells. PIPs are degraded by various enzymes, including PIP phosphatases. The integral membrane Sac1 phosphatases represent a major class of such enzymes. The central role of lipid phosphatases in regulating PIP homeostasis notwithstanding, the biological ...
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Journal of Cellular Physiology, 2005
AbstractSpermatogenesis in the seminiferous epithelium of the mammalian testis is a dynamic cellular event. It involves extensive restructuring at the Sertoli–germ cell interface, permitting germ cells to traverse the epithelium from basal to adluminal compartment.
Jiayi, Zhang +2 more
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AbstractSpermatogenesis in the seminiferous epithelium of the mammalian testis is a dynamic cellular event. It involves extensive restructuring at the Sertoli–germ cell interface, permitting germ cells to traverse the epithelium from basal to adluminal compartment.
Jiayi, Zhang +2 more
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Detection of Myotubularin Phosphatases Activity on Phosphoinositides in vitro and ex vivo
2008Phosphoinositides (PPIn) are important regulators of cellular processes like intracellular protein transport, cellular proliferation, apoptosis, and cytoskeletal organization. The amount and localization of these membrane-bound second messengers are regulated through a set of specific phospholipases, lipid kinases, and phosphatases.
Rohde, Holger Maria +3 more
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Enzyme Assays for Phosphoinositide Kinases and Phosphatases and Inhibitor Screens
In vitro enzyme assays provide sensitive and quantitative approaches to studying activity, identifying substrates or performing inhibitor analysis. These approaches can help to study enzymes that regulate different cellular processes in an organism. In addition, enzyme assays can be used to screen protein inhibitors to identify novel drug candidates ...Mengjin, Gao +4 more
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Innate host defense mechanisms SAC bacteria by regulating phosphoinositide kinases and phosphatases
Autophagy, 2022, Ramnik Xavier, Kimberly Carey
exaly
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease
Trends in Cell Biology, 2002Jack Dixon, Matthew J Wishart
exaly