Results 241 to 250 of about 37,565 (330)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer. [PDF]

Lipids Health Dis
Chytła A, Rattay S, Akgül B, Sztacho M.   +3 more
europepmc   +1 more source

Phosphoinositides of Corynebacterium xerosis [PDF]

Biochemical Journal, 1968
openaire   +2 more sources

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Regulation of NRF2 by stably associated phosphoinositides and small heat shock proteins in response to stress. [PDF]

J Biol Chem
Chen C, Carrillo ND, Chen M, Wen T, Awasthi P, Anderson RA, Cryns VL.   +6 more
europepmc   +1 more source

Author Response: A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

Yiechang Lin, Elaine Tao, James Champion, Ben Corry   +3 more
openalex   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

Regulation of the MDM2-p53 nexus by a nuclear phosphoinositide and small heat shock protein complex. [PDF]

J Biol Chem
Lee JH, Chen M, Wen T, Anderson RA, Cryns VL.   +4 more
europepmc   +1 more source

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, EarlyView.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

TRPV1: from structure to function-a multidimensional target for therapeutic advances. [PDF]

J Zhejiang Univ Sci B
Liu Y, Duan F, Lin R, Shabuerjiang S, Yang F, Aierken A.   +5 more
europepmc   +1 more source