Results 31 to 40 of about 37,565 (330)

Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes

Cellular Physiology and Biochemistry, 2015
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains.
Prasenjit Manna, Sushil K. Jain
doaj   +1 more source

Phosphoinositides in the kidney

Journal of Lipid Research, 2019
Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI kinases and PI phosphatases. The number of PI-metabolizing enzymes exceeds the
Leopoldo Staiano, Maria Antonietta De Matteis   +1 more
doaj   +1 more source

RASSF4: Regulator of plasma membrane PI(4,5)P2. [PDF]

, 2017
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/
Balla, Chang, Chen, Cockcroft, Dickson, Eamonn J. Dickson, Hille, Kim, Liou, Nakatsu, Prakriya, Rawat, van der Weyden   +12 more
core   +1 more source

Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants [PDF]

, 2009
ACAP-type ARF GTPase activating proteins (ARF-GAPs) regulate multiple cellular processes, including endocytosis, secretion, phagocytosis, cell adhesion and cell migration.
Friml, Jiri, Fukuda, Hiroo, Koizumi, Koji, Nakano, Akihiko, Naramoto, Satoshi, Sawa, Shinichiro, Uemura, Tomohiro   +6 more
core   +1 more source

The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction [version 1; referees: 4 approved]

F1000Research, 2016
Phosphoinositides are master regulators of multiple cellular processes: from vesicular trafficking to signaling, cytoskeleton dynamics, and cell growth.
Laura Picas, Frederique Gaits-Iacovoni, Bruno Goud   +2 more
doaj   +1 more source

Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane

Viruses, 2022
The fully assembled influenza A virus (IAV) has on its surface the highest density of a single membrane protein found in nature—the glycoprotein hemagglutinin (HA) that mediates viral binding, entry, and assembly.
Prakash Raut, Bright Obeng, Hang Waters, Joshua Zimmerberg, Julie A. Gosse, Samuel T. Hess   +5 more
doaj   +1 more source

Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption [PDF]

, 2004
BACKGROUND: Gelsolin, an actin capping protein of osteoclast podosomes, has a unique function in regulating assembly and disassembly of the podosome actin filament.
Baker, De Anna, Biswas, Rajat S, Chellaiah, Meenakshi A, Hruska, Keith A   +3 more
core   +3 more sources

Lipid dynamics at dendritic spines

Frontiers in Neuroanatomy, 2014
Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine
Carlos Gerardo Dotti, Jose Antonio Esteban, Maria Dolores eLedesma   +2 more
doaj   +1 more source

Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention

Frontiers in Cell and Developmental Biology, 2023
Phosphoinositides serve as essential players in numerous biological activities and are critical for overall cellular function. Due to their complex chemical structures, localization, and low abundance, current challenges in the phosphoinositide field ...
Alicia Llorente, Ryan M. Loughran, Brooke M. Emerling   +2 more
doaj   +1 more source

Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]

, 2012
Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Albert, AP, Lawrence, KM, Stenbeck, G
core   +2 more sources