Results 41 to 50 of about 37,565 (330)

Phosphoinositides and Photoreceptors [PDF]

Molecular Neurobiology, 2011
The importance of phosphoinositides (phosphorylated phosphatidyl inositol derivatives, PIs) for normal cellular function cannot be overstated. Although they represent a small fraction of the total phospholipid within the cell, they are essential regulators of many cellular functions.
openaire   +2 more sources

Phosphoinositides in New Spaces

Cold Spring Harbor Perspectives in Biology, 2023
Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are regulated via reversible phosphorylation, which is directed by the opposing actions of PI kinases and phosphatases. PIs constitute a minor fraction of the total cellular lipid pool but play pleiotropic roles in multiple aspects of cell biology.
Elizabeth Michele Davies, Christina Anne Mitchell, Harald Alfred Stenmark   +2 more
openaire   +3 more sources

Tipping the scales:Lessons from simple model systems on inositol imbalance in neurological disorders [PDF]

, 2017
Inositol and inositol-containing compounds have signalling and regulatory roles in many cellular processes, suggesting that inositol imbalance may lead to wide-ranging changes in cellular functions.
Abe, Adley, Alberdi, Alers, Alzheimer’s Disease International, Anna D. Frej, Bachhawat, Belmaker, Berridge, Brickner, Buckmaster, Bélanger, Calker, Cataldi, Chang, Chang, Chang, Chang, Chang, Chiu, Cho, Clark, Clements, Cremona, Criollo, Croze, Culbertson, Das, Davanzo, Dean-Johnson, Deranieh, Deranieh, Deranieh, Di Daniel, Drion, Eickholt, Fajutrao, Felberbaum, Fenili, Ferruz, Fischbach, Fischer, Frej, Fu, Ghavami, Grant P. Otto, Greenberg, Griffith, Hartman, Hasegawa, Ho, Hoyer, Irvine, Jiang, Ju, Ju, Kaddurah-Daouk, Kamada, Keith, Kennedy, King, Kirshenbaum, Klopfenstein, Kollros, Konarzewska, Kosta, Kotaria, Kurnasov, Kwan, Lester, Lhuillier, Loewus, Looney, Lopes, Lystad, MacGregor, Macias, Majumder, Martin, Masaki, McKnight, McLaurin, McMahon, Meng, Mizushima, Mohammadpour, Murray, Nonaka, Nozadze, Ohnishi, Otto, O’Donnell, Parthasarathy, Pascente, Pattni, Pereira, Prieto, Puls, Qing, Randise-Hinchliff, Robin S.B. Williams, Sarkar, Saudek, Schewe, Schiebler, Sha, Shaldubina, Shaltiel, Shetty, Shi, Shimon, Silverstone, Singh, Solomonia, Solomonia, Solomonia, Steger, Stransky, Teo, Terbach, Toker, Trushina, Vaden, van Vliet, Vanhaesebroeck, Viard, Vogel, Wang, Warsh, Watanabe, Waugh, Wellard, Whiting, Williams, Williams, Wong, Wu, Wu, Xu, Yamagami, Zeng   +140 more
core   +1 more source

Phosphatidylinositolphosphate phosphatase activities and cancer

Journal of Lipid Research, 2016
Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation.
Simon A. Rudge, Michael J.O. Wakelam
doaj   +1 more source

Phosphoinositide-signaling is one component of a robust plant defense response.

Frontiers in Plant Science, 2014
The phosphoinositide pathway and inositol-1,4,5-triphosphate (InsP3) have been implicated in plant responses to many abiotic stresses; however, their role in response to biotic stress is not well characterized.
Imara Yasmin Perera, Chiu-Yueh eHung, Peter eAspesi Jr, Melissa R Hunter, Aaron eLomax   +4 more
doaj   +1 more source

Changes in membrane lipids drive increased endocytosis following Fas ligation [PDF]

, 2017
Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes.
Degli Esposti, Mauro, Garofalo, Tina, Khosravi Far, Roya, Longo, Agostina, Malorni, Walter, Matarrese, Paola, Misasi, Roberta, Recalchi, Serena, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +1 more source

Taurine Attenuates Streptococcus uberis-Induced Bovine Mammary Epithelial Cells Inflammation via Phosphoinositides/Ca2+ Signaling

Frontiers in Immunology, 2019
Taurine may alleviate the inflammatory injury induced by Streptococcus uberis (S. uberis) infection by regulating intracellular Ca2+ levels. However, the underlying mechanisms remain unclear. Infection leads to subversion of phosphoinositides (PIs) which
Ming Li, Panpan Xi, Yuanyuan Xu, Zhenglei Wang, Xiangan Han, Wenkai Ren, Vanhnaseng Phouthapane, Jinfeng Miao   +7 more
doaj   +1 more source

Structure of the full-length TRPV2 channel by cryo-EM. [PDF]

, 2016
Transient receptor potential (TRP) proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a 'minimal' TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel ...
Cohen, Matthew R, Huynh, Kevin W, Jiang, Jiansen, Lodowski, David T, Moiseenkova-Bell, Vera Y, Samanta, Amrita, Zhou, Z Hong   +6 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Editorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes [PDF]

, 2015
The voltage-sensing phosphatase (VSP) has changed the way we think about both cellular electrical activity and PIPs (phosphatidylinositol phosphates). Originally discovered in 1999 (Chen et al., 1999), these proteins were not recognized as electrically ...
Kohout, Susy C., Villalba-Galea, Carlos A.   +1 more
core   +4 more sources