Results 81 to 90 of about 1,619,431 (240)

Biomarkers of atherosclerotic plaque vulnerability and their clinical significance

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Inflammatory reaction plays a crucial role in the occurence and development of atherosclerosis. Both basic and clinical trials have provided evidence that the expression of inflammatory biomarkers are closely related with the degree of atherosclerosis.
Ran LIU, Hong-jun HAO, Lin-lin LIU, Jing-jing LUO, Jie-xi WEN, Feng GAO   +5 more
doaj  

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Producing Monoclonal Antibodies To Phospholipase A2 [PDF]

, 1985
Monoclonal antibodies were produced to phospholipase A2, a protein allergen of honey bee venom. The hybridoma technique, which involves fusing antibody-producing spleen cells to myeloma cells was used.
Kernie, Marie
core   +2 more sources

Clear cell renal cell carcinoma complicated with PLA2R-associated membranous nephropathy：three cases report and literature review

Linchuang shenzangbing zazhi
ObjectiveTo explore the clinical characteristics， treatment and outcomes of renal cell carcinoma （RCC） combined with phospholipase A2 receptor （PLA2R）-related membranous nephropathy （MN）.MethodsThe clinical and pathological data， diagnosis， treatment ...
Sun Miao-xin, Wu Hao-wen, Wang Ding-ding, Wang Shuang-yu, Chai Wen-xiu, Li Yun, Li Zi-wei, Duan Li-ping   +7 more
doaj   +3 more sources

Anti-Contactin-1-Associated Membranous Nephropathy Presenting With Subsequent Autoimmune Nodopathy

Kidney Medicine
A 70-year-old man presented with biopsy-proven phospholipase A2 receptor--negative membranous nephropathy (MN). Shortly thereafter, he presented with progressive sensorimotor polyneuropathy, initially consistent with an inflammatory demyelinating ...
Ruben Visch, Shoko Vos, Pierre Ronco, Hanna Debiec, Karlien Mul, Tom Nijenhuis, Anne-Els van de Logt   +6 more
doaj   +1 more source

IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor

International Journal of Rheumatology, 2012
Patients with IgG4-related disease (IgG4-RD) share histopathological characteristics that are similar across affected organs. The finding of infiltration with IgG4+ plasma cells in the proper clinical and histopathological contexts connects a large number of clinical entities that were viewed previously as separate conditions.
Khosroshahi, Arezou, Ayalon, Rivka, Beck, Laurence H., Salant, David J., Bloch, Donald, Stone, John   +5 more
openaire   +4 more sources

Phospholipases A1 [PDF]

, 2011
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K., Gregory S. Richmond, Terry K. Smith, Richmond, Gregory S., Smith, Terry K.; id_orcid   +4 more
core   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Renal Phospholipase A2 Receptor and the Clinical Features of Idiopathic Membranous Nephropathy

Chinese Medical Journal, 2017
Background: According to the renal phospholipase A2 receptor (PLA2R) immunohistochemistry, idiopathic membranous nephropathy (iMN) could be categorized into PLA2R-associated and non-PLA2R-associated iMN. This study aimed to examine whether the non-PLA2R-
Ning-Xin Xu, Qiong-Hong Xie, Zhu-Xing Sun, Jia Wang, Yan Li, Liang Wang, Shao-Jun Liu, Jun Xue, Chuan-Ming Hao   +8 more
doaj   +1 more source

Microbiota as the candidate biomarker in pediatric obstructive sleep apnea

Sleep Research, EarlyView.
Abstract Pediatric obstructive sleep apnea (OSA) is a form of sleep‐disordered breathing in children. Recent studies have focused on characterizing microbiota alterations associated with pediatric OSA and identifying microbial features that may have potential value as future biomarkers. The most commonly used approach for microbiota profiling is second‐
Xiaoyan Li, Jingxuan Bai, Ying Xu, Min Yu, Xuemei Gao   +4 more
wiley   +1 more source