Results 81 to 90 of about 40,217 (258)

New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination

Viruses, 2022
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak and COVID-19 vaccination, new-onset and relapsed clinical cases of membranous nephropathy (MN) have been reported.
Qiqi Ma, Xiang Li, Gaosi Xu
doaj   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Phospholipase A2 Receptor (PLA2R1) Sequence Variants in Idiopathic Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2013
The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic membranous nephropathy (iMN). Our recent genome-wide association study showed that genetic variants in an HLA-DQA1 and phospholipase A2 receptor (PLA2R1) allele associate most significantly with biopsy-proven iMN, suggesting that rare genetic variants within the
Coenen, M.J.H., Hofstra, J.M., Debiec, H., Stanescu, H.C., Medlar, A.J., Stengel, B., Boland-Augé, A., Groothuismink, J.M., Groothuismink, J.M., Bockenhauer, D., Powis, S.H., Mathieson, P.W., Brenchley, P.E., Kleta, R., Wetzels, J.F.M., Ronco, P.   +15 more
openaire   +7 more sources

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Secretory Phospholipase A2 Receptor-Mediated Activation of Cytosolic Phospholipase A2 in Murine Bone Marrow-Derived Mast Cells [PDF]

The Journal of Immunology, 2000
Abstract The current study examined the signal transduction steps involved in the selective release of arachidonic acid (AA) induced by the addition of secretory phospholipase A2 (sPLA2) isotypes to bone marrow-derived mast cells (BMMC).
A N, Fonteh, G, Atsumi, T, LaPorte, F H, Chilton   +3 more
openaire   +2 more sources

Bee venom enhances dopaminergic function and behavioral recovery in a murine model of Parkinson's disease

Neuroprotection, EarlyView.
Experimental design and behavioral outcomes of bee venom treatment in a murine model of Parkinson's disease. Mice received an intrastriatal injection of 6‐OHDA into the right hemisphere to induce dopaminergic degeneration. Animals were subsequently treated with l‐DOPA/carbidopa, with or without bee venom (BV) administered intraperitoneally.
Silvia Josefina López‐Pérez, Marco Antonio Noriega‐Ruiz, Alma Karen Lomeli‐Lepe   +2 more
wiley   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

A metabolomic investigation of the effects of vitamin E supplementation in humans

, 2012
Background Vitamin E is a nutrient with both antioxidant and non-antioxidant activities and has been shown to modulate the function of a number of cell types in vitro and in human studies.
John K Lodge, Max Wong, Lodge John K, Lodge, John, Wong, Max, Wong Max   +5 more
core   +1 more source

Effect of Phospholipase Digestion and Lysophosphatidylcholine on Dopamine Receptor Binding [PDF]

, 1984
[3H]Spiperone specific binding by microsomal membranes isolated from sheep caudate nucleus is decreased by trypsin and phospholipase A2 (Vipera russeli), but is insensitive to neuraminidase.
Carvalho, A. P., Duarte, E. P., Oliveira, C. R.   +2 more
core   +1 more source