Results 61 to 70 of about 40,300 (234)

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Resistance to Endotoxic Shock in Phospholipase A2 Receptor-deficient Mice [PDF]

Journal of Biological Chemistry, 1997
Mammals possess various types of secretory phospholipase A2, which differ in the primary structure and tissue distribution. The phosholipase A2 receptor (PLA2R) recognizes group IB phospholipase A2 (PLA2-IB) and mediates the PLA2-IB-induced biological responses in non-digestive organs, including eicosanoid production and contraction of airway smooth ...
K, Hanasaki, Y, Yokota, J, Ishizaki, T, Itoh, H, Arita   +4 more
openaire   +2 more sources

Receptor-binding capability of pancreatic phospholipase A2 is separable from its enzymatic activity [PDF]

, 1993
Mammalian pancreatic phospholipase A2 (PLA2-I) has its specific receptor through which PLA2-I induces a variety of biological responses. In this study, a fundamental relationship between the enzymatic and the receptor-binding activities of PLA2-I was ...
Osamu Ohara, Junji Kishino, Teraoka, Hiroshi, Hiroshi Teraoka, Hitoshi Arita, Arita, Hitoshi, Kishino, Junji, Ishizaki, Jun, Jun Ishizaki, Ohara, Osamu   +9 more
core   +1 more source

Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies

Renal Failure
Background Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb−) has been reported.
Xue Li, Yang Shen, Yanchun Li, Lijie Ma, Qianmei Sun   +4 more
doaj   +1 more source

The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis

Parasites & Vectors, 2021
Background The NF-κB signalling pathway has been reported to be related to liver fibrosis, and we investigated whether the NF-κB signalling pathway is involved in liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis (CssPLA2 ...
Yin-Juan Wu, Qing He, Mei Shang, Ying-Xuan Yin, Ye Li, Xue Du, Xue-Rong Li   +6 more
doaj   +1 more source

The genetic and functional basis of three inherited cutaneous and gastrointestinal diseases in humans [PDF]

, 2014
This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17.
Brooke, Matthew A
core  

Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration. [PDF]

, 2010
BACKGROUND: An early event in the neuropathology of prion and Alzheimer's diseases is the loss of synapses and a corresponding reduction in the level of synaptophysin, a pre-synaptic membrane protein essential for neurotransmission.
Williams Alun, Williams, A, Mourad Tayebi, Bate Clive, Alun Williams, Bate, C, Tayebi, M, Tayebi Mourad, Clive Bate   +8 more
core   +5 more sources

Anti-glomerular basement membrane disease superimposed on membranous nephropathy after coronavirus disease 2019: A case report

Journal of International Medical Research
Membranous nephropathy concurrent with anti-glomerular basement membrane disease is rarely reported. Acute kidney injury is prominent when these diseases coexist. Coronavirus disease 2019 may trigger this superimposition.
Rongrong Hu, Siqi Tang, Chao Li, Yizhen Wei, Peng Xia, Ke Zheng, Yan Qin   +6 more
doaj   +1 more source

Circulating anti-phospholipase A2 receptor antibodies as a diagnostic and prognostic marker in Greek patients with idiopathic membranous nephropathy – a retrospective cohort study

Romanian Journal of Internal Medicine, 2019
Introduction. Circulating autoantibodies against phospholipase A2 receptor (anti-PLA2R) are recognized as key elements in the pathogenesis of idiopathic membranous nephropathy.
Provatopoulou Simella, Kalavrizioti Dimitra, Stangou Maria, Kouri Maria-Nikoleta, Kalliakmani Pantellitsa, Papasotiriou Marios, Papachristou Evangelos, Goumenos Dimitrios S., Papagianni Aikaterini   +8 more
doaj   +1 more source