Results 41 to 50 of about 78,131 (198)

Inhibitory potential of important phytochemicals from Pergularia daemia (Forsk.) chiov., on snake venom (Naja naja)

Journal of Genetic Engineering and Biotechnology, 2016
Pergularia daemia (Forsk.) chiov., is a milk weed of Asclepiadaceae family. In the present study β-sitosterol, β-amyrin, α-amyrin and lupeol were identified in the leaf by GC–MS.
S.T.V. Raghavamma, Nadendla Rama Rao, Garikapati Devala Rao   +2 more
doaj   +1 more source

Autoantibodies against phospholipase A2 receptor in Korean patients with membranous nephropathy. [PDF]

PLoS ONE, 2013
The data were presented in abstract form at the 45(th) meeting of the American Society of Nephrology, October 30-November 04 2012, San Diego, CA, USA. Circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R) are important pathogenic ...
Yun Jung Oh, Seung Hee Yang, Dong Ki Kim, Shin-Wook Kang, Yon Su Kim   +4 more
doaj   +1 more source

Economic Benefit of Anti-PLA2R Antibody Testing in the Diagnosis of Membranous Nephropathy: A Single-Center Cost Analysis

Turkish Journal of Nephrology
Background: This study aimed to evaluate the financial impact of using anti-phospholipase A2 receptor antibody testing instead of kidney biopsy for diagnosing membranous nephropathy.
Asil Demirezen, Nuri Alperen Malkoç, Ömer Faruk Akçay, Saliha Yıldırım, Emre Yaşar, Sena Türkmen, Emre Yaşar, Sena Türkmen, Özlem Gülbahar, Betül Öğüt, İpek Işık Gönül, Galip Güz, Ülver Derici, Yasemin Erten, Kadriye Altok, Özant Helvacı   +15 more
doaj   +1 more source

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß [PDF]

, 2017
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to ...
Bate, C
core   +3 more sources

Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2015
In the 6 years since the discovery of anti-phospholipase A2 receptor (anti-PLA2R) antibodies in the majority of patients with primary membranous nephropathy (MN),1 our understanding of the role of anti-PLA2R in clinical disease has evolved rapidly. The initial small retrospective clinical studies indicated that anti-PLA2R levels could be modulated by ...
openaire   +2 more sources

Anti-Phospholipase A2 Receptor Antibodies and the Pathogenesis of Membranous Nephropathy [PDF]

Nephron Clinical Practice, 2014
Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification of neutral endopeptidase, the type-M phospholipase A₂ receptor ...
Pierre, Ronco, Hanna, Debiec
openaire   +2 more sources

Secondary membranous nephropathy in a patient with myasthenia gravis without thymic disease, and partial remission induced by adrenocorticotropic hormone therapy

SAGE Open Medical Case Reports, 2019
Membranous glomerulonephritis is the most common glomerular disease in adults. Its primary form has been characterized with formation of phospholipase A2 receptor antibodies.
Ramy M Hanna, Farid Arman, Umut Selamet, William D Wallace, Marina Barsoum, Anjay Rastogi, Niloofar Nobakht, Perry Shieh   +7 more
doaj   +1 more source

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]

, 1994
Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M, Cifone, MG, De Maria, R, Lanier, LL, Rippo, MR, Roncaioli, P, Santoni, A, Testi, R   +7 more
core   +2 more sources

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes [PDF]

Aging Cell, 2018
AbstractHutchinson–Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates many normal aging characteristics. This disorder is caused by mutation in the LMNA gene leading to the production of progerin which induces misshapen nuclei, cellular senescence, and aging.
Griveau, Audrey, Wiel, Clotilde, Le Calvé, Benjamin, Ziegler, Dorian, Djebali, Sophia, Warnier, Marine, Martin, Nadine, Marvel, Jacqueline, Vindrieux, David, Bergo, Martin, Bernard, David   +10 more
openaire   +5 more sources