Results 31 to 40 of about 1,619,431 (240)
A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]
, 2009 Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania +40 more
core +1 more source
Advances in Pathogenesis of Idiopathic Membranous Nephropathy
Kidney Diseases, 2020 Background: Membranous nephropathy (MN), a major cause of nephrotic syndrome, has attracted people’s attention in recent years for its growing prevalence.
Zhifeng Xu +4 more
doaj +1 more source
Linchuang shenzangbing zazhi, 2021 The sensitivity of serum anti-M-type phospholipase A2 receptor antibodies（anti-PLA2 R Abs）is 70%～80% in idiopathic membranous nephropathy and the specificity over 95%.This article reviewed the latest research advances on the pathogenesis,diagnosis ...
Wang Hui +3 more
doaj
A phospholipase A2‐linked receptor for PEDF
The FASEB Journal, 2006 Pigment epithelium‐derived factor (PEDF), a 50‐kDa extracellular serpin, is a neurotrophic and antiangiogenic factor for the retina. Its biological functions are independent from its serine protease inhibition potential. Previously we provided evidence for high affinity PEDF‐binding sites and proteins in retina cell‐surfaces ...
Luigi Notari +3 more
openaire +1 more source
The genetic and functional basis of three inherited cutaneous and gastrointestinal diseases in humans [PDF]
, 2014 This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17.
Brooke, Matthew A
core +2 more sources
Nature Communications, 2020 Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the
Jingyuan Xie +119 more
doaj +1 more source
Respiratory Medicine Case Reports, 2021 Lane Hamilton Syndrome is the rare association of idiopathic pulmonary hemosiderosis and Celiac Disease. The definitive pathophysiologic link is unknown, but the syndrome has been described as co-occurring along with other diseases. We describe the first
Scarlett Austin +6 more
doaj +1 more source
Expression of Phospholipase A2 Receptor in Pediatric Hepatitis B Virus-Related Membranous Nephropathy [PDF]
Childhood Kidney Diseases, 2020 Purpose Hepatitis B virus (HBV) infection is among etiologies of secondary membranous nephropathy (MN) in pediatric patients. We evaluated expression of phospholipase A2 receptor (PLA2R), a specific target antigen of primary MN, in pediatric HBV-related ...
Sung-Eun Choi +5 more
doaj +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2021 Tuberculosis (TB)-associated glomerulonephritis is difficult to diagnose that usually presents with hematuria, proteinuria, edema, hypertension, or renal insufficiency, which is similar to symptoms of primary glomerulonephritis.
Manish R. Balwani +3 more
doaj +1 more source
The significance of anti-phospholipase receptor antibodies in a patient with membranous nephropathy
Saudi Journal of Kidney Diseases and Transplantation, 2020 Membranous nephropathy (MN) is the major cause of nephrotic syndrome in adults and may be secondary to systemic lupus erythematosus or malignancy in 25% of patients.
Jayaprakash R Dasari +6 more
doaj +1 more source