Results 51 to 60 of about 1,619,431 (240)

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes [PDF]

Aging Cell, 2018
AbstractHutchinson–Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates many normal aging characteristics. This disorder is caused by mutation in the LMNA gene leading to the production of progerin which induces misshapen nuclei, cellular senescence, and aging.
Griveau, Audrey, Wiel, Clotilde, Le Calvé, Benjamin, Ziegler, Dorian, Djebali, Sophia, Warnier, Marine, Martin, Nadine, Marvel, Jacqueline, Vindrieux, David, Bergo, Martin, Bernard, David   +10 more
openaire   +5 more sources

Predicting the mechanism of phospholipidosis [PDF]

, 2012
The mechanism of phospholipidosis is still not well understood. Numerous different mechanisms have been proposed, varying from direct inhibition of the breakdown of phospholipids to the binding of a drug compound to the phospholipid, preventing breakdown.
Mitchell, JBO, Glen, RC, Glen Robert C, Nigsch Florian, Mussa, HY, Robert Lowe, Florian Nigsch, Robert C Glen, Nigsch, F, Mussa, Hamse Y., Lowe, R, Glen, Robert C., Lowe Robert, John BO Mitchell, Mitchell John BO, Nigsch, Florian, Lowe, Robert, Mussa Hamse Y, Hamse Y Mussa, Mitchell, John B. O., Mitchell, John B. O.; id_orcid   +20 more
core   +5 more sources

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Molecular Dynamics Simulation of Paracetamol with A2 Phospholipase

, 2022
This series of files were used in the preparation of a moelcular dynamics simulation of Paracetamol with the A2 phospholipase receptor to analyse and investigate the behaviour of this interaction.The simulation was conducted using the Gromacs software ...
McKenna, C (via Mendeley Data), McKenna, Conor   +1 more
core   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Molecular Dynamics Simulation of Aspirin with A2 Phospholipase

, 2022
This series of files were used in the preparation of a moelcular dynamics simulation of Aspirin with the A2 phospholipase receptor to analyse and investigate the behaviour of this interaction.The simulation was conducted using the Gromacs software and ...
McKenna, C (via Mendeley Data), McKenna, Conor   +1 more
core   +1 more source

Enhancing Adeno‐Associated Virus 2 Capsid Engineering Through Co‐Evolutionary Coupling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated virus (AAV) has emerged as a leading platform for gene therapy. However, to unlock the full potential, their manufacturing yields, stability, and efficacy must all be improved. Rational design is limited by poor predictability and the potential impact of mutations on multiple important vector properties.
Sirimar Laosinwattana, Yiwen Li, Braulio Carrillo Sanchez, Ayesha Khan, Paul A. Dalby   +4 more
wiley   +1 more source

Supplemental material for Antibodies to M-type phospholipase A2 receptor (PLA₂R) in membranous lupus nephritis

, 2019
Supplemental Material for Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis by E Garcia-Vives, C Solé, T Moliné, A M Alvarez-Rios, M Vidal, I Agraz, J Ordi-Ros and J Cortés-Hernández in ...
J Cortés-Hernández (6338060), C Solé (6338042), I Agraz (6338054), E Garcia-Vives (6338039), J Ordi-Ros (6338057), A M Alvarez-Rios (6338048), M Vidal (6338051), T Moliné (6338045)   +7 more
core   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies

Renal Failure
Background Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb−) has been reported.
Xue Li, Yang Shen, Yanchun Li, Lijie Ma, Qianmei Sun   +4 more
doaj   +1 more source