Results 21 to 30 of about 40,300 (234)

Phospholipase A2 Receptor Antibodies in Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2014
The discovery of the M-type phospholipase A2 receptor (PLA2R) as a major antigen in idiopathic membranous nephropathy (iMN) was a breakthrough and established iMN as an autoimmune disease.1 Subsequent studies confirmed that antibodies against PLA2R were present in approximately 70% of incident iMN patients (reviewed by Hofstra and Wetzels2).
Hofstra, J.M., Wetzels, J.F.
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The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells [PDF]

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
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Phospholipase A2 Receptor Antibody IgG4 Subclass Improves Sensitivity and Specificity in the Diagnosis of Idiopathic Membranous Nephropathy

Kidney & Blood Pressure Research, 2019
Aims: The aim of this study was to develop a new method for detecting anti-phospholipase A2 receptor-IgG4 to improve the sensitivity and specificity in the diagnosis of idiopathic membranous nephropathy (IMN).
Biao Huang, Yi Zhang, Liang Wang, Wenwei Xu, Jue Zhang, Qiuhua Zhang, Huiming Sheng, Zhigang Hu   +7 more
doaj   +1 more source

Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy [PDF]

Nephrology Dialysis Transplantation, 2015
Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis.
T. Stehle, V. Audard, P. Ronco, H. Debiec   +3 more
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Clearance of group X secretory phospholipase A2 via mouse phospholipase A2 receptor [PDF]

, 2001
Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A2 (sPLA2-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types.
Notoya, Mitsuru, Yasunori Yokota, Higashino, Ken-ichi, Hitoshi Arita, Nakano, Kazumi, Yokota, Yasunori, Ishimoto, Yoshikazu, Mitsuru Notoya, Kohji Hanasaki, Hanasaki, Kohji, Kazumi Nakano, Arita, Hitoshi, Ken-ichi Higashino, Yoshikazu Ishimoto   +13 more
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Serumanti-PLA2R antibody predicted treatment outcome in idiopathic membranous nephropathy

Linchuang shenzangbing zazhi, 2021
Objective To explore the predictive value of serum phospholipase A2 receptor antibody in determining the efficacy of rituximab in the treatment of idiopathic membranous nephropathy（IMN）.Methods From August 1,2017 to May 31,2020,a total of 120 IMN ...
Zhang Xue-qin, Jiang Hong, Yang Shu-fen, Zhao Hong-juan, Lu Chen   +4 more
doaj  

Phospholipases A1 [PDF]

, 2011
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K., Gregory S. Richmond, Terry K. Smith, Richmond, Gregory S.   +3 more
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Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2011
The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV ...
Weisong, Qin, Laurence H, Beck, Caihong, Zeng, Zhaohong, Chen, Shijun, Li, Ke, Zuo, David J, Salant, Zhihong, Liu   +7 more
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Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
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Molecular Characterization and In Silico Analyses of Maurolipin Structure as a Secretory Phospholipase A2 (sPLA2) from Venom Glands of Iranian Scorpio maurus (Arachnida: Scorpionida)

Journal of Tropical Medicine, 2022
The venom is a mixture of various compounds with specific biological activities, such as the phospholipase  A2 (PLA2) enzyme present in scorpion venom. PLA2 plays a key role in inhibiting ryanodine receptor channels and has neurotoxic activity.
Parisa Soltan-Alinejad, Hamzeh Alipour, Aboozar Soltani, Qasem Asgari, Amin Ramezani, Davood Mehrabani, Kourosh Azizi   +6 more
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