Results 21 to 30 of about 78,131 (198)
Serumanti-PLA2R antibody predicted treatment outcome in idiopathic membranous nephropathy
Linchuang shenzangbing zazhi, 2021 Objective To explore the predictive value of serum phospholipase A2 receptor antibody in determining the efficacy of rituximab in the treatment of idiopathic membranous nephropathy（IMN）.Methods From August 1,2017 to May 31,2020,a total of 120 IMN ...
Zhang Xue-qin +4 more
doaj
Phospholipase A2 receptor (PLA2R) related membranous nephropathy - not specific for idiopathic cases any more [PDF]
Journal of Nephropathology, 2018 Context: Membranous nephropathy is among the most common causes of nephrotic syndrome in adults. Evidence Acquisitions: PubMed, EBSCO, Web of Science, directory of open access journals (DOAJ), EMBASE, and Google Scholar with keywords of phospholipase A2 ...
Bahar Bastani
doaj +1 more source
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
core +2 more sources
Journal of Tropical Medicine, 2022 The venom is a mixture of various compounds with specific biological activities, such as the phospholipase A2 (PLA2) enzyme present in scorpion venom. PLA2 plays a key role in inhibiting ryanodine receptor channels and has neurotoxic activity.
Parisa Soltan-Alinejad +6 more
doaj +1 more source
The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]
, 2013 The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves +3 more
core +1 more source
Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy [PDF]
Journal of the American Society of Nephrology, 2011 The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV ...
Weisong, Qin +7 more
openaire +2 more sources
Advances in Pathogenesis of Idiopathic Membranous Nephropathy
Kidney Diseases, 2020 Background: Membranous nephropathy (MN), a major cause of nephrotic syndrome, has attracted people’s attention in recent years for its growing prevalence.
Zhifeng Xu +4 more
doaj +1 more source
Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. [PDF]
, 2015 Blood-derived monocytes remove apoptotic cells and terminate inflammation in settings as diverse as atherosclerosis and Alzheimer's disease. They express high levels of the proresolving receptor ALX/FPR2, which is activated by the protein annexin A1 ...
Flower, R.J. +11 more
core +2 more sources
Linchuang shenzangbing zazhi, 2021 The sensitivity of serum anti-M-type phospholipase A2 receptor antibodies（anti-PLA2 R Abs）is 70%～80% in idiopathic membranous nephropathy and the specificity over 95%.This article reviewed the latest research advances on the pathogenesis,diagnosis ...
Wang Hui +3 more
doaj
A phospholipase A2‐linked receptor for PEDF
The FASEB Journal, 2006 Pigment epithelium‐derived factor (PEDF), a 50‐kDa extracellular serpin, is a neurotrophic and antiangiogenic factor for the retina. Its biological functions are independent from its serine protease inhibition potential. Previously we provided evidence for high affinity PEDF‐binding sites and proteins in retina cell‐surfaces ...
Luigi Notari +3 more
openaire +1 more source