Glucocorticoid receptor stabilization: Relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2 [PDF]
, 1983 Glucocorticoid receptors in cytosol preparations from rat liver or mouse L cells are inactivated by phospholipase A2 or calf intestine alkaline phosphatase. Molybdate ion, an inhibitor of a variety of phosphatase enzymes, does not prevent inactivation of
Pratt, William B. +2 more
core +1 more source
Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy [PDF]
, 2018 Anti-phospholipase A2 receptor antibody; Membranous nephropathy; Spontaneous remissionAnticòs del receptor anti-fosfolipasa A2; Nefropatia membranosa; Remissió espontàniaAnticuerpo del receptor anti-fosfolipasa A2; Nefropatía membranosa; Remisión ...
Agraz Pamplona, Irene +5 more
core +1 more source
Phospholipase A2 Receptor Antibodies in Membranous Nephropathy [PDF]
Journal of the American Society of Nephrology, 2014 The discovery of the M-type phospholipase A2 receptor (PLA2R) as a major antigen in idiopathic membranous nephropathy (iMN) was a breakthrough and established iMN as an autoimmune disease.1 Subsequent studies confirmed that antibodies against PLA2R were present in approximately 70% of incident iMN patients (reviewed by Hofstra and Wetzels2).
Hofstra, J.M., Wetzels, J.F.
openaire +2 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. [PDF]
, 2010 Phosphoinositol (PhoIns)-specific phospholipase C enzymes (PLCs) are central to the inositol lipid signaling pathways and contribute to intracellular Ca2+ release and protein kinase C activation. Five distinct classes of PhoIns-specific PLCs are known to
Farquharson, C +4 more
core +2 more sources
Serumanti-PLA2R antibody predicted treatment outcome in idiopathic membranous nephropathy
Linchuang shenzangbing zazhi, 2021 Objective To explore the predictive value of serum phospholipase A2 receptor antibody in determining the efficacy of rituximab in the treatment of idiopathic membranous nephropathy（IMN）.Methods From August 1,2017 to May 31,2020,a total of 120 IMN ...
Zhang Xue-qin +4 more
doaj
Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy [PDF]
Nephrology Dialysis Transplantation, 2015 Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis.
T. Stehle +3 more
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Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk [PDF]
, 2002 Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two ...
Quintel, Michael +11 more
core +2 more sources
Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy [PDF]
Journal of the American Society of Nephrology, 2011 The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV ...
Weisong, Qin +7 more
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Journal of Tropical Medicine, 2022 The venom is a mixture of various compounds with specific biological activities, such as the phospholipase A2 (PLA2) enzyme present in scorpion venom. PLA2 plays a key role in inhibiting ryanodine receptor channels and has neurotoxic activity.
Parisa Soltan-Alinejad +6 more
doaj +1 more source