Results 121 to 130 of about 20,305 (246)

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Secreted Phospholipases A₂ - not just Enzymes: Revisited. [PDF]

Int J Biol Sci, 2022
Ivanušec A, Šribar J, Križaj I.
europepmc   +1 more source

Experimental and computational studies on lipoprotein lipolysis at acidic pH [PDF]

, 2010
Atherosclerosis is a disease of the arteries; its characteristic features include chronic inflammation, extra- and intracellular lipid accumulation, extracellular matrix remodeling, and an increase in extracellular matrix volume.
Lähdesmäki, Katariina
core  

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source

Functional Modulation of Human Macrophages by Secreted Phospholipases A₂: Implications in Cancer. [PDF]

Biomedicines, 2022
Galdiero MR, Mormile I, Granata F, Loffredo S, Detoraki A, Della Casa F, Trocchia ML, Ventrici A, de Paulis A, Rossi FW.   +9 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore [PDF]

, 2018
Cedars, Ari M., Gross, Richard W., Jenkins, Christopher M., Joseph, Susan M., Kelley, John, Kiebish, Michael A., Liu, Xinping, Moon, Sung Ho, Yang, Kui   +8 more
core   +2 more sources

Pharmacokinetics and Anti‐Inflammatory Effects of Intramuscular Betamethasone in Exercised Thoroughbred Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics and pharmacodynamics of betamethasone following intra‐articular administration to horses have been described; however, studies characterizing intramuscular administration are lacking. Twenty‐four horses received an intramuscular dose of 12 mg betamethasone sodium phosphate/betamethasone acetate.
Juliana Sullivan, Jeff Blea, Daniel S. McKemie, Philip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

Inflammatory Effects of Bothrops Phospholipases A₂: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation. [PDF]

Toxins (Basel), 2021
Moreira V, Leiguez E, Janovits PM, Maia-Marques R, Fernandes CM, Teixeira C.   +5 more
europepmc   +1 more source