Secreted Phospholipases A2: Drivers of Inflammation and Cancer. [PDF]
Hidalgo I +4 more
europepmc +1 more source
Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A2 and Cytotoxins. [PDF]
Pucca MB +12 more
europepmc +1 more source
Inflammation, Immunity, and Cardiovascular Diseases
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
New Insights into the Bioenergetic and Immunomodulatory Properties of Phospholipases A<sub>2</sub> from <i>Bothrops diporus</i> Venom. [PDF]
Sasovsky DJ +8 more
europepmc +1 more source
ABSTRACT Wild Laurus nobilis fruits, a well‐known dietary plant, have been documented to alleviate cardiopathy associated with pulmonary fibrosis, but the underlying mechanisms remain largely unspecified. This current study aimed to investigate the potential therapeutic effects of wild L.
Saber Jedidi +5 more
wiley +1 more source
Proteomics and life-history variability of Endogenous Phospholipases A2 Inhibitors (PLIs) in Bothrops jararaca plasma. [PDF]
Serino-Silva C +10 more
europepmc +1 more source
Protective effect of snail secretion filtrate in an in vitro model of mastitis
Abstract Background Bovine mastitis is inflammation of the mammary gland mainly caused by bacterial infections, with relevant economic costs and implications related to antibiotic resistance. In light of the increasing demand for sustainable therapies, this study evaluated the anti‐inflammatory and antioxidant effects of snail secretion filtrate (SSF ...
Gianluca Antonio Franco +5 more
wiley +1 more source
Phospholipases A<sub>2</sub> (PLA<sub>2</sub>s) and Related Peptides from <i>Bothrops</i> Snake Venoms: History, Structure, Pharmacology, and Inhibitors. [PDF]
Santos ICD +13 more
europepmc +1 more source
Extracts of Hormophysa triquetra showed antifungal activity with marked hyphal deformities in Fusarium oxysporum and Alternaria alternata. Light microscopy and SEM confirmed structural alterations despite unchanged radial growth. Cucumber assays validated reduced disease incidence, linked to fatty‐acid–rich metabolites detected by GC–MS.
Shazia Bibi +4 more
wiley +1 more source
Membrane and inhibitor interactions of intracellular phospholipases A2. [PDF]
Mouchlis VD, Dennis EA.
europepmc +1 more source

