Food Science &Nutrition, Volume 14, Issue 6, June 2026.This study elucidates the multi‐targeted mechanisms of Virgin Coconut Oil (CO) as a dietary intervention for ameliorating Diabetic Kidney Disease (DKD). High‐purity medium‐chain fatty acids (MCFAs, primarily octanoic acid [C8:0] and decanoic acid [C10:0]) in CO significantly remodel the gut microbiota by enriching short‐chain fatty acid (SCFA ...
Keke Shao +13 more
wiley +1 more source
Role of Phospholipases A2 in Vascular Relaxation and Sympatholytic Effects of Five Australian Brown Snake, Pseudonaja spp., Venoms in Rat Isolated Tissues. [PDF]
Front Pharmacol, 2021 Vuong NT, Jackson TNW, Wright CE.
europepmc +1 more source
Reproxalap ‐ A Novel Treatment Option for Allergic Conjunctivitis – A Comprehensive Narrative Review
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Allergic conjunctivitis is a prevalent, immune‐mediated hypersensitivity disorder of the ocular surface affecting 10%–20% of the global population. Current therapeutic options, while effective to some extent, are often limited by side effects and inconsistent efficacy.
Sanila Mughal +7 more
wiley +1 more source
INHIBITORY ACTIVITY OF Murraya paniculata AGAINST MYOTOXIC PHOSPHOLIPASES A2
Vitae, 2010 Envenomation by snakes of the genus Bothrops are a health problem in some tropical countries, not only because of the mortality but given the high percentage of physical disabilities it causes.
Tatiana LOBO E. +6 more
doaj
Development of aqueous two-phase systems-based approaches for the selective recovery of metalloproteases and phospholipases A<sub>2</sub> toxins from Crotalus molossus nigrescens venom. [PDF]
Bioresour Bioprocess, 2021 Enriquez-Ochoa D +4 more
europepmc +1 more source
The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets
iNew Medicine, Volume 2, Issue 2, June 2026.The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong +5 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.ABSTRACT Background Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood.
Joe W. Chiles III +23 more
wiley +1 more source
Insights into the antiviral activity of phospholipases A2 (PLA2s) from snake venoms. [PDF]
Int J Biol Macromol, 2020 Teixeira SC +10 more
europepmc +1 more source
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source