Epitope-based antibody development against metalloproteinases and phospholipases A<sub>2</sub> from <i>Deinagkistrodon acutus</i> venom. [PDF]
J Venom Anim Toxins Incl Trop DisBackground: Deinagkistrodon acutus, or the hundred-pace snake, poses severe health risks due to its venom. Envenomation by this snake leads to complications such as hemorrhage, edema, and coagulopathy.
Zhu H +6 more
europepmc +3 more sources
Etomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A<sub>2</sub> and mitochondrial respiration. [PDF]
J Lipid ResMitochondrial fatty acid oxidation serves as an essential process for cellular survival, differentiation, proliferation, and energy metabolism. Numerous studies have utilized etomoxir (ETO) for the irreversible inhibition of carnitine palmitoylcarnitine ...
Moon SH +5 more
europepmc +2 more sources
The involvement of phospholipases A2 in asthma and chronic obstructive pulmonary disease. [PDF]
Mediators Inflamm, 2013 The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest.
Pniewska E, Pawliczak R.
europepmc +2 more sources
Secreted phospholipases A2 of snake venoms: effects on the peripheral neuromuscular system with comments on the role of phospholipases A2 in disorders of the CNS and their uses in industry. [PDF]
Toxins (Basel), 2013 Neuro- and myotoxicological signs and symptoms are significant clinical features of envenoming snakebites in many parts of the world. The toxins primarily responsible for the neuro and myotoxicity fall into one of two categories—those that bind to and ...
Harris JB, Scott-Davey T.
europepmc +2 more sources
Therapeutic Potential of Bee and Scorpion Venom Phospholipase A2 (PLA2): A Narrative Review [PDF]
Iranian Journal of Medical Sciences, 2022 Venomous arthropods such as scorpions and bees form one of the important groups with an essential role in medical entomology. Their venom possesses a mixture of diverse compounds, such as peptides, some of which have toxic effects, and enzymatic peptide ...
Parisa Soltan-Alinejad +3 more
doaj +1 more source
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Snake venoms have been fervently studied for decades for two reasons: 1) high death rate due to snake bites; 2) numerous components of snake venoms prove useful in medicine and treatment of diverse pathologies. Snake venom phospholipases A2 are among the
L. V. Galebskaya +3 more
doaj +1 more source
Phospholipase A2 Biochemistry [PDF]
Cardiovascular Drugs and Therapy, 2008 The phospholipase A(2) (PLA(2)) superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids. The products of this reaction, a free fatty acid, and lysophospholipid have many different important physiological roles.
Burke, John E, Dennis, Edward A
openaire +4 more sources
Kidney & Blood Pressure Research, 2023 Introduction: The disruption of podocyte structure and function are the main pathological mechanism of membranous nephropathy (MN). Phospholipases A2, Group XII B (PLA2G12B) was reported involved in the regulation of MN by interfering with arachidonic ...
Linlin Fu +5 more
doaj +1 more source
Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia [PDF]
PeerJ, 2014 Bothrops punctatus is an endangered, semi-arboreal pitviper species distributed in Panamá, Colombia, and Ecuador, whose venom is poorly characterized.
Maritza Fernández Culma +3 more
doaj +2 more sources
Molecular Characterization of Three Novel Phospholipase A2 Proteins from the Venom of Atheris chlorechis, Atheris nitschei and Atheris squamigera [PDF]
, 2016 Secretory phospholipase A2 (sPLA2) is known as a major component of snake venoms and displays higher-order catalytic hydrolysis functions as well as a wide range of pathological effects.
Chen, Tianbao +5 more
core +8 more sources