Epitope-based antibody development against metalloproteinases and phospholipases A2 from Deinagkistrodon acutus venom [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Deinagkistrodon acutus, or the hundred-pace snake, poses severe health risks due to its venom. Envenomation by this snake leads to complications such as hemorrhage, edema, and coagulopathy.
Haiting Zhu +6 more
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Etomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A2 and mitochondrial respiration [PDF]
Journal of Lipid ResearchMitochondrial fatty acid oxidation serves as an essential process for cellular survival, differentiation, proliferation, and energy metabolism. Numerous studies have utilized etomoxir (ETO) for the irreversible inhibition of carnitine palmitoylcarnitine ...
Sung Ho Moon +5 more
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The Involvement of Phospholipases A2 in Asthma and Chronic Obstructive Pulmonary Disease [PDF]
Mediators of Inflammation, 2013 The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest.
Ewa Pniewska, Rafal Pawliczak
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Secreted Phospholipases A2 of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A2 in Disorders of the CNS and Their Uses in Industry [PDF]
Toxins, 2013 Neuro- and myotoxicological signs and symptoms are significant clinical features of envenoming snakebites in many parts of the world. The toxins primarily responsible for the neuro and myotoxicity fall into one of two categories—those that bind to and ...
John B. Harris, Tracey Scott-Davey
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Therapeutic Potential of Bee and Scorpion Venom Phospholipase A2 (PLA2): A Narrative Review [PDF]
Iranian Journal of Medical Sciences, 2022 Venomous arthropods such as scorpions and bees form one of the important groups with an essential role in medical entomology. Their venom possesses a mixture of diverse compounds, such as peptides, some of which have toxic effects, and enzymatic peptide ...
Parisa Soltan-Alinejad +3 more
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Effective Soybean Oil Degumming by Immobilized Phospholipases A2 from Walterinnesia aegyptia Venom [PDF]
ACS OmegaAbir Ben Bacha, Mona Alonazi
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Snake venoms have been fervently studied for decades for two reasons: 1) high death rate due to snake bites; 2) numerous components of snake venoms prove useful in medicine and treatment of diverse pathologies. Snake venom phospholipases A2 are among the
L. V. Galebskaya +3 more
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Vitae, 2010 Los envenenamientos causados por serpientes del género Bothrops constituyen un problema de salud en algunos países tropicales, no solamente por la mortalidad sino por el alto porcentaje de incapacidades físicas que ocasionan.
Tatiana LOBO E +6 more
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Phospholipase A2 Biochemistry [PDF]
Cardiovascular Drugs and Therapy, 2008 The phospholipase A(2) (PLA(2)) superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids. The products of this reaction, a free fatty acid, and lysophospholipid have many different important physiological roles.
Burke, John E, Dennis, Edward A
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Kidney & Blood Pressure Research, 2023 Introduction: The disruption of podocyte structure and function are the main pathological mechanism of membranous nephropathy (MN). Phospholipases A2, Group XII B (PLA2G12B) was reported involved in the regulation of MN by interfering with arachidonic ...
Linlin Fu +5 more
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