Results 31 to 40 of about 9,957 (215)
The emerging roles of PAF acetylhydrolase
Journal of Lipid Research, 2009 Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs).
Thomas M. McIntyre +2 more
doaj +1 more source
Toxins, 2022 Snakebite envenoming is a pathological condition which may occur in response to the injection of venom. Snake venoms contain a complex mixture of biologically active molecules which are responsible for a broad spectrum of clinical manifestations, ranging
Dabor Resiere +2 more
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Lipases and proteases inhibition by Averrhoa carambola L. fruit extracts
Phytomedicine Plus, 2021 Background: Proteases and phospholipases A2 are involved in processes related to hemostasis. Medicinal plants which contain bioactive phytochemicals, can act as enzymatic modulators.
Daniela Aparecida Oliveira +4 more
doaj +1 more source
Phospholipase A2 as a mechanosensor
Biophysical Journal, 1995 Osmotic swelling of large unilamellar vesicles (LUVs) causes membrane stretching and thus reduces the lateral packing of lipids. This is demonstrated to modulate strongly the catalytic activity of phospholipase A2 (PLA2) toward a fluorescent phospholipid, 1-palmitoyl-2-[(6-pyren-1-yl)]decanoyl-sn-glycero-3-phosphocholine (PPDPC) residing in LUVs ...
Lehtonen, J.Y., Kinnunen, P.K.
openaire +2 more sources
Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]
PLoS ONE, 2013 Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard +3 more
doaj +1 more source
Journal of Lipid Research, 2010 Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes.
Caroline Subra +11 more
doaj +1 more source
Phospholipase A2 and inflammation
Molecular Medicine Today, 1995 Increased expression of secreted group II phospholipase A 2 (sPLA2) is associated with inflammation 1.This enzyme can promote a variety of potentially harmful events, which have been attributed to its catalytic activity. However, the possibility that sPLA 2 may also exert actions that do not depend on its catalytic activity has generally not been ...
Lomonte, Bruno +2 more
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Mammalian Phospholipase A2: Phospholipase A2 Receptor
Biological and Pharmaceutical Bulletin, 2004 The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire +3 more sources
Proteome and Peptidome of Vipera berus berus Venom
Molecules, 2016 Snake venom is a rich source of peptides and proteins with a wide range of actions. Many of the venom components are currently being tested for their usefulness in the treatment of many diseases ranging from neurological and cardiovascular to cancer.
Aleksandra Bocian +7 more
doaj +1 more source
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, EarlyView.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source