Results 31 to 40 of about 241,697 (248)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Novel Bradykinin-Potentiating Peptides and Three-Finger Toxins from Viper Venom: Combined NGS Venom Gland Transcriptomics and Quantitative Venom Proteomics of the Azemiops feae Viper

Biomedicines, 2020
Feae’s viper Azemipos feae belongs to the Azemiopinae subfamily of the Viperidae family. The effects of Viperidae venoms are mostly coagulopathic with limited neurotoxicity manifested by phospholipases A2. From A.
Vladislav V. Babenko, Rustam H. Ziganshin, Christoph Weise, Igor Dyachenko, Elvira Shaykhutdinova, Arkady N. Murashev, Maxim Zhmak, Vladislav Starkov, Anh Ngoc Hoang, Victor Tsetlin, Yuri Utkin   +10 more
doaj   +1 more source

The emerging roles of PAF acetylhydrolase

Journal of Lipid Research, 2009
Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs).
Thomas M. McIntyre, Stephen M. Prescott, Diana M. Stafforini   +2 more
doaj   +1 more source

Inflammation and Oxidative Stress in Snakebite Envenomation: A Brief Descriptive Review and Clinical Implications

Toxins, 2022
Snakebite envenoming is a pathological condition which may occur in response to the injection of venom. Snake venoms contain a complex mixture of biologically active molecules which are responsible for a broad spectrum of clinical manifestations, ranging
Dabor Resiere, Hossein Mehdaoui, Remi Neviere   +2 more
doaj   +1 more source

Lipases and proteases inhibition by Averrhoa carambola L. fruit extracts

Phytomedicine Plus, 2021
Background: Proteases and phospholipases A2 are involved in processes related to hemostasis. Medicinal plants which contain bioactive phytochemicals, can act as enzymatic modulators.
Daniela Aparecida Oliveira, Marcus Vinicius Cardoso Trento, Pedro Henrique Souza Cesar, Mariana Aparecida Braga, Silvana Marcussi   +4 more
doaj   +1 more source

Lipocortin inhibition of extracellular and intracellular phospholipases A2 is substrate concentration dependent [PDF]

, 1987
Hydrolysis of Escherichia coli membrane phospholipids by pancreatic phospholipase A2 was inhibited by lipocortin from human monocytes in a substrate dependent manner. Inhibition was completely overcome at substrate concentrations above 250 μM. Lipocortin
C. Comera, Bosch, H. van den, Mynbeek, G., Prieur, B., H. van den Bosch, L. Jordan, F. Russo-Marie, Rothhut, B., Russo-Marie, F., B. Prieur, G. Mynbeek, Jordan, J., Aarsman, A.J., Comera, C., A.J. Aarsman, B. Rothhut   +15 more
core   +1 more source

Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]

PLoS ONE, 2013
Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard, Valerie A Novakovic, Jan T Rasmussen, Gary E Gilbert   +3 more
doaj   +1 more source

Phospholipase A2 as a mechanosensor

Biophysical Journal, 1995
Osmotic swelling of large unilamellar vesicles (LUVs) causes membrane stretching and thus reduces the lateral packing of lipids. This is demonstrated to modulate strongly the catalytic activity of phospholipase A2 (PLA2) toward a fluorescent phospholipid, 1-palmitoyl-2-[(6-pyren-1-yl)]decanoyl-sn-glycero-3-phosphocholine (PPDPC) residing in LUVs ...
Lehtonen, J.Y., Kinnunen, P.K.
openaire   +2 more sources

Group I and Group II Phospholipases A2 in Serum in Uraemia [PDF]

, 1993
Summary: Time-resolved fluoroimmunoassays were used for the detection of pancreatic group I and synovial-type group II phospholipases A2 in sera of patients suffering from chronic renal failure before and after haemodialysis. The concentration of group I
Peuravuori, Heikki J., J. Peuravuori, Hitoshi Funatomi, Timo J. Nevalainen, Nevalainen, Timo J., Funatomi, Hitoshi   +5 more
core   +1 more source

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins[S]

Journal of Lipid Research, 2010
Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes.
Caroline Subra, David Grand, Karine Laulagnier, Alexandre Stella, Gérard Lambeau, Michael Paillasse, Philippe De Medina, Bernard Monsarrat, Bertrand Perret, Sandrine Silvente-Poirot, Marc Poirot, Michel Record   +11 more
doaj   +1 more source