Results 41 to 50 of about 241,697 (248)

Crystallization and preliminary X-ray diffraction analysis of three myotoxic phospholipases A2 from Bothrops brazili venom [PDF]

, 2012
Two myotoxic and noncatalytic Lys49-phospholipases A2 (braziliantoxin-II and MT-II) and a myotoxic and catalytic phospholipase A2 (braziliantoxin-III) from the venom of the Amazonian snake Bothrops brazili were crystallized.
Comparetti, Edson J., Gartuzo, Elaine C. G. [UNESP], Marangoni, Sergio, Fernandes, Carlos A. H. [UNESP], Ponce-Soto, Luis Alberto, Soares, Andreimar M., Huancahuire-Vega, Salomon, Costa, Tassia R., Fernandes, Carlos A. H., Pagotto, Ivan [UNESP], Comparetti, Edson J. [UNESP], Pagotto, Ivan, Fontes, Marcos R. M., Gartuzo, Elaine C. G., Fontes, Marcos R. M. [UNESP]   +14 more
core   +1 more source

Mammalian Phospholipase A2: Phospholipase A2 Receptor

Biological and Pharmaceutical Bulletin, 2004
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire   +3 more sources

Phospholipase A2 and inflammation

Molecular Medicine Today, 1995
Increased expression of secreted group II phospholipase A 2 (sPLA2) is associated with inflammation 1.This enzyme can promote a variety of potentially harmful events, which have been attributed to its catalytic activity. However, the possibility that sPLA 2 may also exert actions that do not depend on its catalytic activity has generally not been ...
Lomonte, Bruno, Tarkowski, Andrej, Hanson, Lars Ake   +2 more
openaire   +4 more sources

Proteome and Peptidome of Vipera berus berus Venom

Molecules, 2016
Snake venom is a rich source of peptides and proteins with a wide range of actions. Many of the venom components are currently being tested for their usefulness in the treatment of many diseases ranging from neurological and cardiovascular to cancer.
Aleksandra Bocian, Małgorzata Urbanik, Konrad Hus, Andrzej Łyskowski, Vladimír Petrilla, Zuzana Andrejčáková, Monika Petrillová, Jaroslav Legath   +7 more
doaj   +1 more source

Role of Phospholipases A2 as Anti-Covid 19

, 2020
In this review trial has been made for the search of anti-covid 19, so my idea depends on the choice of phospholipases A2 as anti-covid 19 depending on the following evidences: Phospholipases (PLs) are a ubiquitous group of enzymes that share the ...
Abdel Fattah, Mohy El Din
core   +1 more source

Phospholipases A1 [PDF]

, 2011
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K., Gregory S. Richmond, Terry K. Smith, Richmond, Gregory S., Smith, Terry K.; id_orcid   +4 more
core   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Spectrophotometric determination of lipases, lysophospholipases, and phospholipases

Journal of Lipid Research, 1984
Spectrophotometric techniques for determining the activities of lipases, lysophospholipases, and phospholipases are reviewed. These methods involve the use of thioester substrate analogs as well as omega-nitrophenyl derivatives of the corresponding ...
A A Farooqui, W A Taylor, C E Pendley, 2nd, J W Cox, L A Horrocks   +4 more
doaj   +1 more source

Secretory Phospholipase A2s in Insulin Resistance and Metabolism

Frontiers in Endocrinology, 2021
The phospholipases A2 (PLA2) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past,
Michael S. Kuefner
doaj   +1 more source