Results 41 to 50 of about 271,068 (255)
Phospholipase A2 and inflammation
Molecular Medicine Today, 1995 Increased expression of secreted group II phospholipase A 2 (sPLA2) is associated with inflammation 1.This enzyme can promote a variety of potentially harmful events, which have been attributed to its catalytic activity. However, the possibility that sPLA 2 may also exert actions that do not depend on its catalytic activity has generally not been ...
Lomonte, Bruno +2 more
openaire +4 more sources
Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]
PLoS ONE, 2013 Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard +3 more
doaj +1 more source
Journal of Lipid Research, 2010 Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes.
Caroline Subra +11 more
doaj +1 more source
Initiator-promotor coupling of phospholipases D and A2 in platelets upon cholesterol incorporation [PDF]
, 1992 Since phospholipases exist within a membrane lipid environment, it is not unreasonable to assume that cholesterol capable of changing the lipid environment can effect the coupling relationship among the signal transducing components.
N. Kochhar +3 more
core +1 more source
Mammalian Phospholipase A2: Phospholipase A2 Receptor
Biological and Pharmaceutical Bulletin, 2004 The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire +3 more sources
Proteome and Peptidome of Vipera berus berus Venom
Molecules, 2016 Snake venom is a rich source of peptides and proteins with a wide range of actions. Many of the venom components are currently being tested for their usefulness in the treatment of many diseases ranging from neurological and cardiovascular to cancer.
Aleksandra Bocian +7 more
doaj +1 more source
Regulatory Functions of Phospholipase A2
Critical Reviews in Immunology, 1997 Phospholipase A2 (PLA2) plays crucial roles in diverse cellular responses, including phospholipid digestion and metabolism, host defense and signal transduction. PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF ...
Makoto, Murakami +4 more
openaire +4 more sources
Phospholipases A2: structure and function
, 2005 Phospholipases A2 (PLA2) are an example of peripheral membrane proteins that must first bind to the phospholipid interface to allow phospholipid hydrolysis to occur.
Wilton, David C.
core +1 more source
Role of Phospholipases A2 as Anti-Covid 19
, 2020 In this review trial has been made for the search of anti-covid 19, so my idea depends on the choice of phospholipases A2 as anti-covid 19 depending on the following evidences: Phospholipases (PLs) are a ubiquitous group of enzymes that share the ...
Abdel Fattah, Mohy El Din
core +1 more source
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source