Results 21 to 30 of about 271,068 (255)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Phospholipase A2 Biochemistry [PDF]

Cardiovascular Drugs and Therapy, 2008
The phospholipase A(2) (PLA(2)) superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids. The products of this reaction, a free fatty acid, and lysophospholipid have many different important physiological roles.
Burke, John E, Dennis, Edward A
openaire   +4 more sources

Phospholipases A1 [PDF]

, 2011
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K., Gregory S. Richmond, Terry K. Smith, Richmond, Gregory S.   +3 more
core   +1 more source

Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis [PDF]

, 2003
The action of secreted phospholipases A2 in skin is thought to be essential for epidermal barrier homeostasis. The incomplete knowledge of presence and functions of the novel secreted phospholipase A2 subtypes in skin prompted us to explore their ...
Gurrieri, Silvia, Schadow, A., Kaszkin, M., Ghomashchi, F., Furstenberger, S., G. Singer, A., Ghomashchi, Farideh, Gelb, M.,, Gelb, Michael H., Haas, U., Haas, Ulrike, Lambeau, G., Schadow, Alexia, Pfeilschifter, Josef, Kaszkin, Marietta, Gurrieri, S., Singer, Alan G., Pfeilschifter, J., Fürstenberger, Gerhard, Lambeau, Gérard   +19 more
core   +1 more source

Subcellular localization of the phospholipases A of rat heart: evidence for a cytosolic phospholipase A1.

Journal of Lipid Research, 1985
During myocardial ischemia increased levels of lysoglycerophospholipids have been reported which may be deleterious to myocardial function. Phospholipases are presumed to be important in the regulation of this process.
G Nalbone, K Y Hostetler
doaj   +1 more source

Lysosomal phospholipase A2

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019
Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor.
James A, Shayman, John J G, Tesmer
openaire   +2 more sources

Signal-activated phospholipase regulation of leukocyte chemotaxis

Journal of Lipid Research, 2009
Signal-activated phospholipases are a recent focus of the rapidly growing field of lipid signaling. The extent of their impact on the pathways regulating diverse cell functions is beginning to be appreciated.
Martha K. Cathcart
doaj   +1 more source

Evaluation of the Brazilian functional fruit Morinda citrifolia as phospholipases A2 and proteases modulator

Phytomedicine Plus, 2021
Morinda citrifolia is a plant widely consumed as food and used in folk medicine. However, there is little scientific information regarding its therapeutic properties. In this study, aqueous extracts from the peel and pulp of M.
Tamara Rezende Marques, Mariana Aparecida Braga, Pedro Henrique Souza Cesar, Nilton Pereira de Souza, Rodrigo Martins Fráguas, Daniela Aparecida Oliveira, Marcus Vinicius Cardoso Trento, Silvana Marcussi   +7 more
doaj   +1 more source

Identification of Two Secreted Phospholipases A2 in Human Epidermis [PDF]

, 2000
Phospholipases A2 are enzymes that catalyze the release of fatty acids from the sn-2 position of phospholipids. Fatty acids have been suggested to play a key role in the barrier function of the epidermis.
Tarroux, Roger, Ceruti, Isabelle, Charveron, Marie, Simon, Marie-Françoise, Chap, Hugues, Maury, Eric, Redoules, Daniel, Prévost, Marie-Claude   +7 more
core   +1 more source

The relationship between lipoprotein-associated phospholipase A2 with cardiovascular risk factors in testosterone deficiency

Urology Research and Practice, 2019
Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) which is believed to play a role in atherosclerotic inflammatory process due to its function in hydrolysis of phospholipids and release of pro-inflammatory products, is considered as a novel ...
Mustafa Keleşoğlu, Fuat Kızılay, Burcu Barutçuoğlu, Güneş Başol, Fulden Saraç, Işıl Mutaf, Bülent Semerci   +6 more
doaj   +1 more source