Results 31 to 40 of about 9,843 (241)
FASEB BioAdvances, Volume 4, Issue 12, Page 775-797, December 2022., 2022 Abstract During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface.
Alba Rudolf Vegas +6 more
wiley +1 more source
Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]
J. Thromb. Haemost. 2009 (7), 2096-2105, 2009 To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Constraints on the multiplicity of the most massive stars known: R136 a1, a2, a3, and c [PDF]
A&A 679, A36 (2023), 2023 The most massive stars known to date are R 136 a1, a2, a3, and c within the central cluster R 136a of the Tarantula nebula in the Large Magellanic Cloud (LMC), with reported masses in excess of 150-200$M_\odot$. However, the mass estimation of these stars relies on the assumption that they are single. We collected three epochs of spectroscopy for R 136
arxiv +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019 Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor.
James A. Shayman, John J.G. Tesmer
openaire +3 more sources
Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]
PLoS ONE, 2013 Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard +3 more
doaj +1 more source
Clinical Implant Dentistry and Related Research, Volume 24, Issue 6, Page 776-791, December 2022., 2022 Abstract Background The lateral maxillary sinus augmentation (MSA) procedure has good predictability in terms of the success of bone regeneration with a low incidence of postoperative infections, estimated between 2% and 5.6%. Although the use of antibiotics is an established and standardized prophylactic measure for MSA procedures, the addition of ...
Lorenzo Mordini +4 more
wiley +1 more source
Lysosomal Phospholipase A2 and Phospholipidosis [PDF]
Molecular and Cellular Biology, 2006 A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. LPLA2 is ubiquitously expressed but is most highly expressed in alveolar macrophages. Double conditional gene targeting was employed to elucidate the function of LPLA2. LPLA2-deficient mice (Lpla2-
Hiraoka, Miki +6 more
openaire +4 more sources
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 Transduction efficiency and immune responses hinder the application of recombinant adeno‐associated viral (rAAV) vectors in gene therapy. Here, Han et al. describe a new combined strategy for AAV capsid engineering and obtain several AAV variants with higher liver transduction efficiency and less immune activation.
Jiabao Han +9 more
wiley +1 more source