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Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase. [PDF]
Biology of reproduction, 2002 The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) accounts for almost the entire selenium content of mammalian testis. PHGPx is abundantly expressed in spermatids as active peroxidase but is transformed to an oxidatively inactivated protein in mature sperm, where it is a major constituent of the mitochondrial capsule in the ...
FORESTA, CARLO +5 more
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PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE
Phosphorus and Sulfur and the Related Elements, 1988In acute inflammation the activated leukocytes generate cytotoxic oxygen free radicals. The role of these radical species in the cellular damage following an acute inflammatory reaction is well known. On the other hand the extent of the cellular damage must be dependent on both the rate of the free-radical generation and the scavenging capacity of the ...
MAIORINO, MATILDE +2 more
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Free Radical Biology and Medicine, 1997
1-linoleoyl lysophosphatidylcholine hydroperoxide is a substrate of GSH peroxidase (GPx) both purified from bovine erythrocytes and nonpurified from rat liver. The initial reaction rate for bovine erythrocyte GPx with 1-linoleoyl lysophosphatidylcholine hydroperoxide is about 76 and 95% of the reaction rate for hydrogen peroxide and linoleic acid ...
H S, Marinho, F, Antunes, R E, Pinto
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1-linoleoyl lysophosphatidylcholine hydroperoxide is a substrate of GSH peroxidase (GPx) both purified from bovine erythrocytes and nonpurified from rat liver. The initial reaction rate for bovine erythrocyte GPx with 1-linoleoyl lysophosphatidylcholine hydroperoxide is about 76 and 95% of the reaction rate for hydrogen peroxide and linoleic acid ...
H S, Marinho, F, Antunes, R E, Pinto
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Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase
Gene Expression Patterns, 2006The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) is indispensable for murine embryonic development; yet, the cellular mechanisms leading to embryonic death around gastrulation are still unclear. To investigate PHGPx expression patterns during embryogenesis, we performed a detailed analysis that revealed a complex expression ...
Manuela, Schneider +5 more
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Free Radical Research Communications, 1991
A comparative study has been carried out on the general reactivity of lipid hydroperoxides in liposomes, biological membranes and lipoproteins with two Se-dependent peroxidases: Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX).
MAIORINO, MATILDE +3 more
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A comparative study has been carried out on the general reactivity of lipid hydroperoxides in liposomes, biological membranes and lipoproteins with two Se-dependent peroxidases: Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX).
MAIORINO, MATILDE +3 more
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The Journal of Nutrition, 1995
Phospholipid hydroperoxide glutathione peroxidase (PHGPX) and classical glutathione peroxidase (GPX1) are encoded by separate genes with only about 40% amino acid and nucleic acid sequence identity. To determine the response of tissue PHGPX expression to dietary Se level and to compare these responses with those for GPX1, weanling male rats were fed ...
X G, Lei +3 more
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Phospholipid hydroperoxide glutathione peroxidase (PHGPX) and classical glutathione peroxidase (GPX1) are encoded by separate genes with only about 40% amino acid and nucleic acid sequence identity. To determine the response of tissue PHGPX expression to dietary Se level and to compare these responses with those for GPX1, weanling male rats were fed ...
X G, Lei +3 more
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1993
Glutathione peroxidases are considered essential for the prevention of lipid peroxidation in biomembranes (1). Whereas the “classical” tetrameric Glutathione peroxidases (GPX) only reduce hydroperoxy fatty acids previously cleaved from phospholipids by phospholipases, a monomeric variant called phospholipid hydroperoxide glutathione peroxidase (PHGPX ...
R. Brigelius-Flohé +5 more
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Glutathione peroxidases are considered essential for the prevention of lipid peroxidation in biomembranes (1). Whereas the “classical” tetrameric Glutathione peroxidases (GPX) only reduce hydroperoxy fatty acids previously cleaved from phospholipids by phospholipases, a monomeric variant called phospholipid hydroperoxide glutathione peroxidase (PHGPX ...
R. Brigelius-Flohé +5 more
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Purification of phospholipid hydroperoxide glutathione peroxidase from bovine retina
Current Eye Research, 1993A low molecular size peroxidase with a high affinity for phospholipid hydroperoxide was purified from bovine retina by sequential extraction with low and high ionic strength buffer, followed by ammonium sulfate fractionation, chromatography on an ultraspherogel column and Protein PAK-SP column.
K W, Lam, L, Wang, B S, Hong, D, Treble
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European Journal of Biochemistry, 1983
Selenium‐containing glutathione peroxidase (EC 1.11.1.9) was purified 6000‐fold from bovine red blood cells to apparent homogeneity. Lipoxygenase (EC 1.13.11.12) was enriched 20‐fold from soybean acetone powder. Linoleic acid was peroxidized with lipoxygenase and then used as a substrate in the glutathione peroxidase reaction.
A, Grossmann, A, Wendel
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Selenium‐containing glutathione peroxidase (EC 1.11.1.9) was purified 6000‐fold from bovine red blood cells to apparent homogeneity. Lipoxygenase (EC 1.13.11.12) was enriched 20‐fold from soybean acetone powder. Linoleic acid was peroxidized with lipoxygenase and then used as a substrate in the glutathione peroxidase reaction.
A, Grossmann, A, Wendel
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