Results 101 to 110 of about 487 (166)

Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertility [PDF]

, 2007
To investigate the physiological effects of mitochondrial phospholipid hydroperoxide glutathione peroxidase (mPHGPx) overexpression during early male germ cell differentiation, we have generated transgenic mice bearing the rat mPhgpx coding sequence ...
CARLOMAGNO, Gianfranco, LENZI, Andrea, GANDINI, Loredana, BOITANI, Carla, MANGIA, Franco, PUGLISI, Rossella, BEVILACQUA, Arturo, STEFANINI, Mario   +7 more
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Human liver microsomal glutathione transferase Substrate specificity and important protein sites [PDF]

, 1993
Human liver microsomal glutathione transferase displays the following glutathione peroxidase/transferase activities: dilinoleoylphosphatidylcholine hydroperoxide (0.03 and 0.17 μmolmin · mg, unactivated and N-ethylmaleimide-activated enzyme, respectively)
Andersson, C., Bergman, T., E. Mosialou, C. Andersson, BERGMAN, T, R. Morgenstern, JORNVALL, H, G. Lundqvist, T. Bergman, Lundqvist, G., ANDERSSON, C, Mosialou, E., MORGENSTERN, R, ANDERSSON, G, LUNDQVIST, G, MOSIALOU, E, H. Jörnvall, Morgenstern, R., G. Andersson, Andersson, G., Jörnvall, H.   +20 more
core   +1 more source

Oxidative stress leads to the formation of esterified erythro- and threo-dihydroxy-fatty acids in HepG2 cells

Redox Biology
Oxidative stress plays a central role in pathophysiology. To assess oxidative stress, sensitive methods are required to monitor the cellular damage caused by reactive oxygen species.
Lilli Scholz, Luca M. Wende, Michel A. Chromik, Nadja Kampschulte, Nils Helge Schebb   +4 more
doaj   +1 more source

Phospholipid hydroperoxide glutathione peroxidase in bull spermatozoa provides a unique marker in the quest for semen quality analysis [PDF]

, 2009
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoperoxidase accounting for most of the selenium content in mammalian testis, which has been found to be linked to fertility in humans. In this study, we addressed the issue whether PHGPx
Monaci M, Sylla L, L. SYLLA, STRADAIOLI, Giuseppe, Maiorino M., G. STRADAIOLI, M. MONACI, MAIORINO, MATILDE   +7 more
core   +1 more source

Targeting ferroptosis for improved radiotherapy outcomes in HPV‐negative head and neck squamous cell carcinoma

Molecular Oncology
To enhance the efficacy of radiotherapy (RT) in human papillomavirus (HPV)‐negative head and neck squamous cell carcinoma (HNSCC), we explored targeting ferroptosis, a regulated cell death process.
Joo Kyung Noh, Min Kyeong Lee, Yeonseo Lee, Minji Bae, Soonki Min, Moonkyoo Kong, Jung Woo Lee, Su Il Kim, Young Chan Lee, Seong‐Gyu Ko, Seon Rang Woo, Young‐Gyu Eun   +11 more
doaj   +1 more source

Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK‐fusion‐positive lung cancer

Molecular Oncology
Cancers can develop resistance to treatment with ALK tyrosine kinase inhibitors (ALK‐TKIs) via emergence of a subpopulation of drug‐tolerant persister (DTP) cells that can survive initial drug treatment long enough to acquire genetic aberrations.
Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura   +8 more
doaj   +1 more source

GenX induces cochlear hair cell injury via System Xc⁻-Gpx4-Fsp1 ferroptosis axis

陆军军医大学学报
Objective To investigate the role and mechanism of ferroptosis in cochlear hair cell injury induced by exposure to ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate (GenX).
LIANG Zhengwei, LIANG Zhengwei, HONG Huihui   +2 more
doaj   +1 more source

Lindane disturbs the capacity of Saccharomyces cerevisiae to scavenge lipid hydroperoxides via phospholipid hydroperoxide glutathione peroxidase causing cell death [PDF]

, 2004
Reactive oxygen species (ROS) are by-products of aerobic metabolism in cells. Pollutants such as lindane may raise its production, causing cell damages in biomolecules as lipids.
Pita, T, Ferreira, R, Alves-Pereira, I
core   +1 more source

Differential response and susceptibility to oxidative stress in mouse lung fibroblasts heterozygous for phospholipid hydroperoxide glutathione peroxidase (GPx4) [PDF]

, 2006
Thesis (Ph. D.)--University of Washington, 2006.Phospholipid hydroperoxide glutathione peroxidase (GPx4) is a member of the family of selenium dependent enzymes that catalyze the reduction of cell membrane-bound phospholipid hydroperoxides in situ and ...
Garry, Michael R
core   +2 more sources

Biological role of hepoxilins: Upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress? [PDF]

, 2007
The 12S-lipoxygenase (12S-LOX) pathway of arachidonic acid (AA) metabolism is bifurcated at 12(S)-hydroperoxy-5Z,8Z,10E (12S-HpETE) in the reduction route to form 12S-hydroxy-eicosatetraenoic acid (12S-HETE) and in 8(S/R)-hydroxy-11(S),12S-trans ...
Deva, R., Ciccoli, R., Nigam, S., Siafaka-Kapadai, A., Zafiriou, M.P.   +4 more
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