Results 91 to 100 of about 487 (166)

Distribution of glutathione peroxidases glutathione reductase in rat brain mitochondria [PDF]

, 1991
The distribution of glutathione reductase (GR), glutathione peroxidase (GPx) and phospholipid hydroperoxide glutathione peroxidase (PHGPx) in isolated rat brain mitochondria was investigated.
Lars Ernster, Ernster, Lars, Enrico Panfili, Sandri, Gabriella, Panfili, Enrico, Gabriella Sandri   +5 more
core   +1 more source

Little effects of Insulin-like Growth Factor-I on testicular atrophy induced by hypoxia

BMC Urology, 2006
Background Insulin-like Growth Factor-I (IGF-I) supplementation restores testicular atrophy associated with advanced liver cirrhosis that is a condition of IGF-I deficiency.
Casares Amelia, Diaz-Sanchez Matias, Puche Juan, Garcia-Fernandez Maria, Castilla-Cortázar Inma, Diez-Caballero Fernando, Aliaga-Montilla M Aurelia, Rodriguez-Borrajo Coronación, Gonzalez-Barón Salvador   +8 more
doaj   +1 more source

ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ATF4 activates the transcription of SCO2 to increase SCO2 expression that further stimulates p38/ERK1 signals in MAPK pathway, ultimately promoting proliferation and migration while inhibiting apoptosis and ferroptosis of lung cancer cells. ABSTRACT Ferroptosis is a specific cell death form resulting from the iron‐dependent lipid peroxidation ...
Liang Yu, Sheng Zhang, Jinxi He, Bo Ma, Xuyang Song, Rui Qiu, Bo Yu   +6 more
wiley   +1 more source

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, Volume 40, Issue 8, Page 5119-5131, August 2026.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source

The selenium-independent phospholipid hydroperoxide glutathione peroxidase from Theobroma cacao (TcPHGPX) protects plant cells against damages and cell death [PDF]

Proteins from the glutathione peroxidase (GPX) family, such as GPX4 or PHGPX in animals, are extensively studied for their antioxidant functions and apoptosis inhibition.
Priminho Pirovani, Carlos, Macêdo Ferreira, Monaliza, do Carmo Santos, Maria Luíza, Martins Alves, Akyla Maria, Micheli, Fabienne, Araújo Santos, Taís, Dos Santos Lopes, Natasha   +6 more
core   +1 more source

Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells. [PDF]

, 2001
Burkitt Lymphoma (BL) cells are highly sensitive to suboptimal growth conditions and undergo apoptosis when seeded at low cell density or reduced serum concentration.
Conrad, M., Suppmann, S., Brielmeier, M., Bechet, J.-M., Bornkamm, G.W., Laux, G.   +5 more
core  

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, Volume 293, Issue 15, Page 4508-4532, August 2026.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Immunohistochemical Detection of Human Gastrointestinal Glutathione Peroxidase in Normal Tissues and Cultured Cells with Novel Mouse Monoclonal Antibodies [PDF]

, 2001
This is the first report to describe the successful detection of human gastrointestinal glutathione peroxidase in normal tissues by Western blotting and immunohistochemical staining techniques. Four hybridoma clones producing monoclonal antibodies (MAbs)
Yasuhito Nakagawa, Fumiya Obata, Hirotaka Imai, Isao Okayasu, Hiroyoshi Komatsu, Hiroyuki Mitomi   +5 more
core   +1 more source

ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure

Particle and Fibre Toxicology, 2019
Background Nano-titanium dioxide (nano-TiO2) is amongst the most widely utilized engineered nanomaterials (ENMs). However, little is known regarding the consequences maternal ENM inhalation exposure has on growing progeny during gestation. ENM inhalation
Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, William T. Goldsmith, Andrya J. Durr, Garrett K. Fink, Timothy R. Nurkiewicz, John M. Hollander   +7 more
doaj   +1 more source

First Tetraploa Genome and Multi‐Omics Analysis Reveal Key Plant‐Microbe‐Soil Interactions for Salt Tolerance and Yield Improvement of Wheat

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4748-4765, August 2026.
ABSTRACT Salinity is a major threat to global agricultural productivity of staple crops such as wheat. Although microbial‐based solutions hold promise for alleviating salinity stress, practical implementation is hindered by insufficient mechanistic characterization of bioinoculants and their interactions with plants.
Cheng‐Wei Qiu, Shuo Zhang, Zi‐Feng Gao, Zhong‐Hua Chen, Chulong Zhang, Mohamed Abdelalim Ali, Feibo Wu   +6 more
wiley   +1 more source