Results 71 to 80 of about 487 (166)

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid, Maria Maqsood, Nimrah Ashraf, Farzeen Asghar, Nauman Khalid   +4 more
wiley   +1 more source

Regulation of Cyclooxygenase and 12-Lipoxygenase Catalysis by Phospholipid Hydroperoxide Glutathione Peroxidase in A431 Cells [PDF]

, 2008
Regulation of arachidonate metabolism in human epidermoid carcinoma A431 cells by phospholipid hydroperoxide glutathione peroxidase (PHGPx) and cytosolic glutathione peroxidase (GPx1) was studied. In order to study the effect of reduced glutathione (GSH)
CHEN, CHING-CHUN;LIN, SHWU-BIN;CHANG, WEN-CHANG, 陳清俊;林淑萍;張文昌   +1 more
core  

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Lizard neuroendocrine disruptor assessment by Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4/PHGPx) expression [PDF]

, 2012
Phospholipid hydroperoxide glutathione peroxidase (GPx4/PHGPx) is a most abundant selenoprotein in the brain and GPx4 null mice die in utero at midgestation or knockdown of GPx4 during mammalian embryogenesis disturbs brain development.
CIARCIA, GAETANO, GUERRIERO, GIULIA, TROCCHIA, SAMANTHA, Ferraro C.   +3 more
core   +1 more source

The Role of Peroxiredoxin 6 in Cell Signaling

Antioxidants, 2018
Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses glutathione and π glutathione S-transferase to complete its ...
José A. Arevalo, José Pablo Vázquez-Medina   +1 more
doaj   +1 more source

Cloning and Expression Analysis of Chicken Phospholipid‐Hydroperoxide Glutathione Peroxidase

Animal Biotechnology, 2003
Phospholipid-hydroperoxide glutathione peroxidase (GPX4 or PHGPX) is a unique selenium dependent glutathione peroxidase that reduces phospholipid, cholesterol, and cholesteryl ester hydroperoxides. Phospholipid-hydroperoxide glutathione peroxidase has been shown to exist as both a 197 amino acid mitochondrial targeting protein and as a 170 amino acid ...
Byung-Whi, Kong, Hyunggee, Kim, Douglas N, Foster   +2 more
openaire   +2 more sources

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Efeitos do zinco sobre os sistemas de degradação de peróxidos de células neurais [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaZinco na sua forma ionica livre e mantido em concentracoes muito baixas nas celulas de mamiferos.
Souza, Luiz Felipe de
core  

Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase 4 GPx4 [PDF]

, 2007
Phospholipid hydroperoxide glutathione peroxidase GPx4 is a moonlighting selenoprotein, which has been implicated in anti oxidative defense, sperm development, and cerebral embryogenesis.
Krauss, N., Kuhn, H., Scheerer, P., Höhne, W., Borchert, A., Wessner, H., Gerth, C.   +6 more
core   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source