Results 51 to 60 of about 487 (166)

Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene [PDF]

, 2006
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoprotein belonging to the family of glutathione peroxidases. PHGPx has long been considered a major antioxidant that, in cooperation with vitamin E, protects biomembranes.
Nayernia, K., Boehm, D., Michelmann, Hans Wilhelm, Tangat, Y., Glander, H.-J., Engel, Wolfgang, Diaconu, Mihaela, Kuehn, Hartmut, Schreiber, Gudrun, Haidl, G.   +9 more
core   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human

EMBO Molecular Medicine, 2013
Elevated oxidative stress is closely associated with obesity. Emerging evidence shows that instead of being a consequence of obesity, oxidative stress may also contribute to fat formation.
Yi‐Cheng Chang, Yu‐Hsiang Yu, Jin‐Yuh Shew, Wei‐Jei Lee, Juey‐Jen Hwang, Yen‐Hui Chen, Yet‐Ran Chen, Pei‐Chi Wei, Lee‐Ming Chuang, Wen‐Hwa Lee   +9 more
doaj   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

Regulation of the yeast phospholipid hydroperoxide glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7 [PDF]

, 2004
The GPX2 gene encodes a homologue of phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae. The GPX2 promoter contains three elements the sequence of which is completely consistent with the optimal sequence for the Yap1 response ...
Shingo Izawa, Maeta, Kazuhiro, Inoue, Yoshiharu, Takatsume, Yoshifumi, Izawa, Shingo, Kazuhiro Maeta, Yoshiharu Inoue, Tsuzi, Daisuke, Daisuke Tsuzi, Yoshifumi Takatsume   +9 more
core   +1 more source

Involvement of Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase as an Antiapoptotic Factor

Neurosignals, 2001
Although reactive oxygen species (ROS) such as superoxide and hydroperoxide are known to induce apoptotic cell death, little is known as to the apoptotic death signaling of mitochondrial ROS. Recent evidence has suggested that antioxidant enzymes in mitochondria may be responsible for the regulation of cytochrome c release and apoptotic cell death ...
K, Nomura, H, Imai, T, Koumura, Y, Nakagawa   +3 more
openaire   +2 more sources

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Mouse models for Glutathione Peroxidase 4 (GPx4). [PDF]

, 2011
The selenoperoxidase glutathione peroxidase 4 (GPx4 – also frequently referred to as phospholipid hydroperoxide glutathione peroxidase, PHGPx) is one of the eight glutathione peroxidases in mammals, but the only one known to be essential for early ...
Conrad, M., Marcus Conrad
core   +1 more source

Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels [PDF]

, 2005
OBJECTIVE: To clarify the role of carnitine supplementation in idiopathic asthenozoospermia and to look for a rationale for its use in asthenozoospermic patients. DESIGN: Blind clinical study. SETTING: Academic.
C. Foresta, ROVERI, ANTONELLA, FORESTA, CARLO, ROVERATO, ALBERTO, A. Garolla, A. ROVERATO, A. Roveri, F. Ursini, GAROLLA, ANDREA, URSINI, FULVIO, M. Maiorino, MAIORINO, MATILDE   +11 more
core  

Induction and Marker Selection of Embryogenic-like Callus from the Hypocotyl of Pinus thunbergii

Plants
To induce embryogenic callus from Pinus thunbergii vegetative organs, and deeply understand the internal mechanism of the process, an orthogonal experimental design of three factors and four levels and proteome analysis were adopted.
Jing Dai, Lijuan Gao, Mengyu Zhang, Jing Liu, Peng Meng   +4 more
doaj   +1 more source