Results 61 to 70 of about 487 (166)

Transcriptomic Response of Chinese Yew (Taxus chinensis) to Cold Stress

Frontiers in Plant Science, 2017
Taxus chinensis is a rare and endangered shrub, highly sensitive to temperature changes and widely known for its potential in cancer treatment. How gene expression of T. chinensis responds to low temperature is still unknown. To investigate cold response
Xianghua Yu, Xianghua Yu, Delong Meng, Delong Meng, Delong Meng, Liyuan Ma, Liyuan Ma, Jin Hu, Jin Hu, Yili Liang, Yili Liang, Xueduan Liu, Xueduan Liu, Huaqun Yin, Huaqun Yin, Hongwei Liu, Hongwei Liu, Xiaojia He, Diqiang Li   +18 more
doaj   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Distinct regulatory mechanism of yeast GPX2 encoding phospholipid hydroperoxide glutathione peroxidase by oxidative stress and a calcineurin/Crz1-mediated Ca2+ signaling pathway [PDF]

, 2004
The GPX2 gene encodes a homologue of mammalian phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae. Previously, we have reported that the oxidative stress-induced expression of GPX2 is strictly regulated by Yap1 and Skn7 ...
Shingo Izawa, Maeta, Kazuhiro, Inoue, Yoshiharu, Takatsume, Yoshifumi, Izawa, Shingo, Kazuhiro Maeta, Yoshiharu Inoue, Tsuzi, Daisuke, Daisuke Tsuzi, Yoshifumi Takatsume   +9 more
core   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Host–Microbe Mechanisms of Fusobacterium nucleatum in Colorectal Cancer

Molecular Oral Microbiology, EarlyView.
Fusobacterium nucleatum and colorectal cancer. ABSTRACT The oral‐derived pathobiont Fusobacterium nucleatum has increasingly been implicated in colorectal cancer (CRC) progression through its ability to modulate inflammatory, immunological, and molecular pathways. F.
Hadda Lyzandra Austríaco Leite, Fernanda Ferreira Lopes   +1 more
wiley   +1 more source

Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma [PDF]

, 2013
Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) is the only known enzyme able to reduce lipid peroxides bound to cell membranes. Moreover it has been involved in apoptosis and can influence intracellular signaling.
Felíu, Juan E., Casado, Enrique, Castro Carpeño, Javier de, Renart, Jaime, Cejas, Paloma, García-Cabezas, Miguel Angel, Fresno Vara, Juan Ángel, Espinosa, Enrique, González Barón, Manuel, Belda-Iniesta, Cristobal   +9 more
core   +1 more source

Development of a bispecific CDH17-GUCY2C ADC bearing the ferroptosis inducer RSL3 for the treatment of colorectal cancer

Cell Death Discovery
Colorectal cancer is a malignant tumor of the colon or rectum, with approximately 150,000 new cases each year. Current treatment strategies, such as surgery, chemotherapy, radiotherapy, and immunotherapy, face challenges ranging from cancer recurrence ...
Ying Zhang, Jing Du, Xiaohong Cui, Yuhang Ling, Chengwu Tang   +4 more
doaj   +1 more source

Changes in Selenoprotein P in Substantia Nigra and Putamen in Parkinson's Disease

Journal of Parkinson’s Disease, 2012
Oxidative stress and oxidized dopamine contribute to the degeneration of the nigrostriatal pathway in Parkinson's disease (PD). Selenoproteins are a family of proteins containing the element selenium in the form of the amino acid selenocysteine, and many
Frederick P. Bellinger, Arjun V. Raman, Rachel H. Rueli, Miyoko T. Bellinger, Andrea S. Dewing, Lucia A. Seale, Marilou A. Andres, Jane H. Uyehara-Lock, Lon R. White, G. Webster Ross, Marla J. Berry   +10 more
doaj   +1 more source

Speciation and adaptive evolution reshape antioxidant enzymatic system diversity across the phylum Nematoda

BMC Biology, 2020
Background Nematodes have evolved to survive in diverse ecological niches and can be a serious burden on agricultural economy, veterinary medicine, and public health.
Lian Xu, Jian Yang, Meng Xu, Dai Shan, Zhongdao Wu, Dongjuan Yuan   +5 more
doaj   +1 more source

Estrogen Selectively Up-Regulates the Phospholipid Hydroperoxide Glutathione Peroxidase in the Oviducts [PDF]

Endocrinology, 2005
The oviduct plays a crucial role in mammalian reproduction by providing an optimal environment for the final maturation and transport of gametes, fertilization, and early embryonic development. It is now recognized that these reproductive events in vitro can be either negatively or positively affected by reactive oxygen species such as hydrogen ...
Jérome, Lapointe, Sarah, Kimmins, Leslie A, Maclaren, Jean-François, Bilodeau   +3 more
openaire   +2 more sources