Results 81 to 90 of about 487 (166)

Avaliação da expressão do citocromo P4501A1 hepático e das defesas antioxidantes em ratos tratados com albendazol e mebendazol [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.O albendazol (ABZ) e o mebendazol (MBZ) são dois fármacos derivados benzimidazólicos com marcada atividade antihelmíntica, amplamente utilizados pela população ...
Locatelli, Claudriana
core  

Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages [PDF]

, 2002
Selenium (Se) and selenoproteins such as glutathione peroxidases are necessary for the proper development and fertilizing capacity of sperm cells. Phospholipid hydroperoxide glutathione peroxidase (PHGPx, E.C.
LENZI, Andrea, GANDINI, Loredana, Alberto Bertoni, Federica Tramer, Enrico Panfili, Fulvio Micali, Gabriella Sandri   +6 more
core   +1 more source

Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia

Cellular & Molecular Biology Letters
Phospholipid Hydroperoxide Gluthatione Peroxidase also called Glutathione Peroxidase 4 is one of the 25 described human selenoproteins. It plays an essential role in eliminating toxic lipid hydroxy peroxides, thus inhibiting ferroptosis and favoring cell
Patrick Auberger, Cécile Favreau, Coline Savy, Arnaud Jacquel, Guillaume Robert   +4 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, Volume 16, Issue 8, Page 1501-1508, August 2026.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Phospholipid hydroperoxide glutathione peroxidase: Expression pattern during testicular development in mouse and evolutionary conservation in spermatozoa [PDF]

, 2004
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a selenoprotein belonging to the family of glutathione peroxidases and has been implicated in antioxidative defense and spermatogenesis. PHGPx accounts for almost the entire selenium content of
Nayernia, Karim, Wennemuth, Gunther, Kleene, Kenneth C., Engel, Wolfgang, Diaconu, Mihaela, Kuehn, Hartmut, Aumüller, Gerhard, Schwandt, Iris   +7 more
core   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Maternal reproductive health: Expression patterns of antioxidant enzyme selenoproteins of post-implantation embryos conceived by ethanol-treated murine mothers supplemented with α-tocopherol

Asian Pacific Journal of Reproduction, 2017
Objective: To investigate if the protective effect of α-tocopherol against the impact of ethanol on brain morphogenesis involved the activity of the selenoproteins phospholipid hydroperoxide glutathione peroxidase (PHGPx; GPx4) and selenoprotein P (SelPP)
Gliceria B Ramos, Noel F Alfonso, Glenn G Oyong, Aleli Jillian L Sia   +3 more
doaj   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Phospholipid Hydroperoxide Glutathione Peroxidase almost thirty years later [PDF]

, 2010
Phospholipid hydroperoxide glutathione peroxidase (PHGPx), now known as GPx-4, was discovered in 1982 as a second glutathione peroxidase (GPx) distinct from GPx-1 because it could peculiarly protect membrane lipid peroxidation in the presence of Vitamin ...
MAIORINO, MATILDE
core