Results 121 to 130 of about 31,335 (237)

Modeling the Histogenetic Switch Between Enameloid and Enamel

Evolution &Development, Volume 28, Issue 3, September 2026.
This evo–devo exploration of ~550,000 histogenetic simulations forming dentine, enameloid, and enamel identifies 38 independent ways to induce the enameloid–enamel transition, with delayed matrix vesicle secretion (SVO‐) emerging as the key modification, providing new insights into the origin of enamel in early osteichthyans.
Guillaume Houée, Jérémie Bardin, Damien Germain, Nicolas Goudemand   +3 more
wiley   +1 more source

Obesity Disrupts CtBP2‐Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen, Kenta Kainoh, Kenji Saito, Takaaki Matsuda, Daichi Yamazaki, Yuto Kobari, Ayumi Nakata, Nao Aono‐Soma, Takafumi Miyamoto, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Motohiro Sekiya   +15 more
wiley   +1 more source

Deciphering the Protein Phosphorylation Dynamics Triggered by Seconds of Force Stimulation. [PDF]

Mol Cell Proteomics
Yang N, Sing Pun S, Wong EOY, Dai S, Li X, Leung M, Burlingame A, Wang ZY, Yang M, Lu Y, An Y, Zhang Y, Yang Z, Yu W, Li N.   +14 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

PD-1/LAG-3 signaling rewires T-cells via MYC inhibition. [PDF]

Signal Transduct Target Ther
Chocarro L, Fernández-Rubio L, Ausin K, Blanco E, Echaide M, Vilaplana B, Santamaría E, Fernández-Irigoyen J, Kochan G, Escors D.   +9 more
europepmc   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Selected monosaccharides in cancer: Metabolic routing, post‐translational modification, immunity and therapeutic potential

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Glucose, galactose, mannose and fructose can either fuel or fight tumours by rewiring metabolism and immunity. Their context‐dependent double‐edged nature suggests that precisely targeted monosaccharide interventions could become a new pillar of precision oncology.
Qin Ouyang, Ke Gao, Haojie Lu, Shu Zhang
wiley   +1 more source

Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in <i>Dictyostelium discoideum</i> in Response to Two Different Chemorepellents. [PDF]

Cells
Uddin SZ, Rijal R, Pilling D, Gomer RH.
europepmc   +1 more source

Studies on the phosphoproteins of brain. 3. Phosphorylserine sequences in brain phosphoprotein [PDF]

Biochemical Journal, 1961
openaire   +2 more sources

Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism, mitochondrial function and myogenesis, yet ...
Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel   +12 more
wiley   +1 more source