Results 81 to 90 of about 18,478 (212)

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, Volume 13, Issue 14, 9 March 2026.
CGRP interacts with HMEC‐1 by binding to surface receptors, influencing the downstream FAK/AKT/VEGF signaling pathway, and promoting the secretion of ANGPTL4 from vascular endothelial cells into the bone microenvironment. This, in turn, regulates the differentiation of BMSCs into osteoblasts, thus promoting bone formation. ABSTRACT Bone angiogenesis is
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Phosphoproteomics Illuminates Opioid Actions

Biochemistry, 2018
Opioids are widely used analgesic medications with a high potential for tolerance and dependence and represent a frequent cause of death due to overdose. Opioids mediate their actions via a family of opioid G protein coupled receptors. Elucidating the biochemical mechanism(s) responsible for both the therapeutic and deleterious side effects of opioids ...
Tao Che, Bryan L. Roth
openaire   +3 more sources

HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]

, 2016
open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare, Len, Alice C.L., Shivkumar, Maitreyi, Starling, Shimona   +3 more
core   +2 more sources

Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) [PDF]

, 2015
Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1.
Baillie, George, Sin, Yuan Yan
core   +1 more source

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source

Purification of Cortactin Using Anion Exchange Chromatography [PDF]

, 2014
Cortactin is an actin-binding protein that has been shown to be involved in cellular migration and metastases in cancer. Bacterially expressed and purified cortactin protein is often used in in vitro assays to examine cortactin’s role in promoting cell ...
Priester, Jacob
core   +1 more source

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants [PDF]

, 2016
Viruses manipulate host factors to enhance their replication and evade cellular restriction. We used multiplex tandem mass tag (TMT)-based whole cell proteomics to perform a comprehensive time course analysis of >6500 viral and cellular proteins during ...
Antrobus, R, Greenwood, EJ, Lehner, PJ, Matheson, NJ, van den Boomen, DJ, Wals, K, Williamson, JC   +6 more
core   +2 more sources

Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis

Aging Cell, Volume 25, Issue 3, March 2026.
Aging is associated with a gut‐specific decline in magnesium (Mg), which accelerates intestinal aging and aggravates colitis in aged mice. Mechanistically, Mg deficiency reshapes the phosphoproteome and N‐glycoproteome, destabilizing adhesion complexes.
Rou Zhang, Meiling Ge, Meng Hu, Yanjie Zhao, Baochen Chong, Wanmeng Li, Jia Yu, Ying Lu, Siyu He, Jiao Wang, Jirong Yue, Hai‐Ning Chen, Heng Xu, Yong Peng, Peng Lei, Zuyun Liu, Lunzhi Dai   +16 more
wiley   +1 more source

Systems Biology of Recombinant 2G12 and 353/11 mAb Production in CHO-K1 Cell Lines at Phosphoproteome Level

Proteomes
Background: Chinese hamster ovary (CHO) cells are extensively used in the pharmaceutical industry for producing complex proteins, primarily because of their ability to perform human-like post-translational modifications.
Eldi Sulaj, Felix L. Sandell, Linda Schwaigerlehner, Gorji Marzban, Juliane C. Dohm, Renate Kunert   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, Volume 20, Issue 2, Page 541-554, February 2026.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source