Results 91 to 100 of about 38,220 (259)
European Journal of Clinical Investigation, EarlyView.This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano +3 more
wiley +1 more source
Biologia Plantarum, 2014 Exposure to low temperatures is one of the most important factors that generate abiotic stress in plants, and the rapid accumulation of soluble sugars belongs to significant metabolic responses to cold stress. The accumulation of soluble sugars may be at
D. Sitnicka, S. Orzechowski
doaj +1 more source
The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]
, 2015 The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika +2 more
core +2 more sources
First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus
The FEBS Journal, EarlyView.The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi +15 more
wiley +1 more source
Measurement of the Proteinase Inhibitors of the Bovine Pancreas by Radioimmunoassay [PDF]
, 1976 Bovine pancreas contains two polypeptide trypsin inhibitors that are not homologous and differ in their inhibitory activity towards chymotrypsin, kallikrein, elastase, and other serine proteinases. The Kunitz inhibitor and the Kazal inhibitor are present
Fink, Edwin +2 more
core +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, EarlyView.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
Crystal structure and evolution of a prokaryotic glucoamylase [PDF]
, 2003 The first crystal structures of a two-domain, prokaryotic glucoamylase were determined to high resolution from the clostridial species Thermoanaerobacterium thermosaccharolyticum with and without acarbose.
Aleshin, Alexander +4 more
core +3 more sources
The FEBS Journal, EarlyView.l‐serine levels in the human brain are maintained by the phosphorylated pathway, a three‐step process catalyzed by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP). These enzymes assemble in a metabolon called the serinosome. The double R27S/D32G PSP variant was identified in the brain of
Silvia Sacchi +10 more
wiley +1 more source
Proceedings, 2019 Enzymes are increasingly used as biocatalysts for the production of Active Pharmaceutical [...]
Marco Terreni +5 more
doaj +1 more source
Histopathology, EarlyView.MTAP immunohistochemistry (IHC) was evaluated as a diagnostic tool for peritoneal mesothelioma by comparing it with CDKN2A homozygous deletion (HD) detected by FISH. Results showed low concordance between MTAP IHC and CDKN2A HD, suggesting MTAP IHC is not reliable for predicting CDKN2A HD in peritoneal mesothelioma. Further studies are needed.
Andrea Quaranta +14 more
wiley +1 more source