British Journal of Pharmacology, EarlyView.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Glycogen metabolic genes are involved in trehalose-6-phosphate synthase-mediated regulation of pathogenicity by the rice blast fungus Magnaporthe oryzae. [PDF]
, 2013 © 2013 Badaruddin et al.Editor - Peter N. Dodds, Commonwealth Scientific and Industrial Research Organisation (CSIRO), AustraliaThis work was funded by the Biotechnology and Biological Sciences Research Council and a European Research Council Advanced ...
AE Stellwagen +61 more
core +3 more sources
Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease [PDF]
, 2021 Marta Migocka-Patrzałek +1 more
openalex +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
A foszforilációs-defoszforilációs jelátviteli útvonalak kölcsönhatásai a szabad gyökök által kiváltott jelátviteli pályákkal = Cross-talk between phosphorylation-dephosphorylation and free radical-mediated signal transduction pathways [PDF]
, 2006 A peroxinitrit humán keratinocita (HaCaT) sejtekben intracelluláris kalcium mobilizációt okoz. Igazoltuk a kalcium mobilizáció szerepét mind az apoptotikus, mind a nekrotikus sejthalálban.
Bai, Péter +7 more
core
The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]
, 2015 The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika +2 more
core +2 more sources
Mitochondrial DNA Depletion Syndrome 1 (MTDPS1)—A Novel Cause of Premature Ovarian Insufficiency
Clinical Genetics, EarlyView.We describe a woman with MNGIE due to a novel homozygous TYMP nonsense variant and propose MNGIE as the cause of her premature ovarian insufficiency—a rarely reported association—highlighting the need to consider mitochondrial disease in unexplained POI, especially in atypical, consanguineous presentations. ABSTRACT Mitochondrial DNA depletion syndrome
Michael Matheou +3 more
wiley +1 more source
Biologia Plantarum, 2014 Exposure to low temperatures is one of the most important factors that generate abiotic stress in plants, and the rapid accumulation of soluble sugars belongs to significant metabolic responses to cold stress. The accumulation of soluble sugars may be at
D. Sitnicka, S. Orzechowski
doaj +1 more source
The adenylate cyclase receptor complex and aqueous humor formation. [PDF]
, 1984 The secretory tissue of the eye, the ciliary processes, contains an enzyme receptor complex, composed of membrane proteins, the catalytic moiety of the enzyme adenylate cyclase, a guanyl nucleotide regulatory protein (or N protein), and other features ...
Caprioli, J, Sears, M
core +1 more source
Similar Microbial Communities Found on Two Distant Seafloor Basalts. [PDF]
, 2015 The oceanic crust forms two thirds of the Earth's surface and hosts a large phylogenetic and functional diversity of microorganisms. While advances have been made in the sedimentary realm, our understanding of the igneous rock portion as a microbial ...
Chong, Lauren S +3 more
core +3 more sources