Results 31 to 40 of about 40,216 (223)
Biomolecules, 2015 Alternative redox stimuli such as pervanadate or hypoxia/reoxygenation, induce transcription factor NF-κB by phospho-tyrosine-dependent and proteasome-independent mechanisms.
Sarah Cullen +2 more
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Tyrosine Kinases and Phosphatases: Enablers of the Porphyromonas gingivalis Lifestyle
Frontiers in Oral Health, 2022 Tyrosine phosphorylation modifies the functionality of bacterial proteins and forms the basis of a versatile and tunable signal transduction system. The integrated action of tyrosine kinases and phosphatases controls bacterial processes important for ...
Richard J. Lamont, Daniel P. Miller
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Protein Clusters in Phosphotyrosine Signal Transduction
Journal of Molecular Biology, 2018 Signal transduction systems based on tyrosine phosphorylation are central to cell-cell communication in multicellular organisms. Typically in such a system, the signal is initiated by activating tyrosine kinases associated with transmembrane receptors ...
B. Mayer, Ji Yu
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Frontiers in Pharmacology, 2023 Tyrosine kinases are crucial signaling components of diverse biological processes and are major therapeutic targets in various malignancies and immune-mediated disorders.
Krisztina Futosi +7 more
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Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology
Frontiers in Cell and Developmental Biology, 2021 The Nck family of modular adaptor proteins, including Nck1 and Nck2, link phosphotyrosine signaling to changes in cytoskeletal dynamics and gene expression that critically modulate cellular phenotype.
Mabruka Alfaidi +4 more
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Phosphotyrosine — a new protein modification [PDF]
Trends in Biochemical Sciences, 1982 Tyrosine protein kinases carry out a newly described form of protein modification - phosphorylation of tyrosine residues. The transforming proteins of certain tumor viruses are tyrosine protein kinases and unscheduled phosphorylation of tyrosine in cellular proteins appears to be crucial for malignant transformation by these viruses.
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Quantitation of Phosphotyrosine Signals in Human Prostate Cell Adhesion Sites
BioTechniques, 2000 A simple method is described for the quantitation of phosphotyrosine signaling in human prostate cell cultures. The phosphotyrosine signals are observed by standard immunohistochemistry techniques, and the resulting digital images are analyzed using the ...
Anne E. Cress
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A new flavor in phosphotyrosine recognition [PDF]
Structure, 1995 The phosphotyrosine-binding (PTB) domain, recently identified in a number of proteins, specifically recognizes tyrosine-phosphorylated sequences in other proteins. Although similar in function to the well-studied SH2 domain, the PTB domain appears to be structurally unrelated.
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LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses
eLife, 2020 LAR-type receptor phosphotyrosine-phosphatases (LAR-RPTPs) are presynaptic adhesion molecules that interact trans-synaptically with multitudinous postsynaptic adhesion molecules, including SliTrks, SALMs, and TrkC.
Alessandra Sclip, Thomas C Südhof
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Design and Synthesis of Phosphotyrosine Peptidomimetic Prodrugs [PDF]
Journal of Medicinal Chemistry, 2006 A novel approach to the intracellular delivery of aryl phosphates has been developed that utilizes a phosphoramidate-based prodrug approach. The prodrugs contain an ester group that undergoes reductive activation intracellularly with concomitant expulsion of a phosphoramidate anion.
Hugo, Garrido-Hernandez +3 more
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