Results 41 to 50 of about 40,216 (223)
BMC Microbiology, 2016 BackgroundHighly virulent strains of the gastric pathogen Helicobacter pylori encode a type IV secretion system (T4SS) that delivers the effector protein CagA into gastric epithelial cells.
J. Lind +8 more
semanticscholar +1 more source
Lymphocyte dysmetabolism: an immunocytochemical comparative approach in IDDM and control subjects
European Journal of Histochemistry, 2009 We have investigated by immuno-electron microscopy the presence of phosphotyrosine in cells as a whole and in different cell districts (nucleus, cytoplasm, plasma membrane, and mitochondria) in peripheral blood lymphocytes of IDDM (insulindependent ...
A Pugnaloni +3 more
doaj +1 more source
Phosphotyrosine isosteres: past, present and future [PDF]
Organic & Biomolecular Chemistry, 2020 In this Review, Cerulli and Kritzer describe the past, present, and future potential of medicinal chemistry approaches to mimicking phosphotyrosine.
Robert A. Cerulli, Joshua A. Kritzer
openaire +2 more sources
Phosphotyrosine-Mediated Regulation of Enterohemorrhagic
mBio, 2018 Enteric pathogens with low infectious doses rely on the ability to orchestrate the expression of virulence and metabolism-associated genes in response to environmental cues for successful infection.
Colin D. Robertson +4 more
doaj +1 more source
Toward quantitative phosphotyrosine profiling in vivo [PDF]
Seminars in Cell & Developmental Biology, 2012 Tyrosine phosphorylation is a dynamic reversible post-translational modification that regulates many aspects of cell biology. To understand how this modification controls biological function, it is necessary to not only identify the specific sites of phosphorylation, but also to quantify how phosphorylation levels on these sites may be altered under ...
Johnson, Hannah, White, Forest M.
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Phosphotyrosine Phosphatases in Cancer Diagnostic and Treatment
Recent Patents on DNA & Gene Sequences, 2010 The activation of proteins by post-translational modification represents an important cellular mechanism for regulating most aspects of biological organization and control, including growth, development, homeostasis, and cellular communication. The complexity of protein modification includes phosphorylation and dephosphorylation, on proteins of ...
Tiscornia, María Mercedes +3 more
openaire +3 more sources
Scalable phosphotyrosine enrichment with SH2 superbinder enables deep profiling of EGF responses
The EMBO JournalPhosphotyrosine signaling plays a critical role in many biological processes, from cell proliferation to immune response. Despite its importance, proteomic studies of tyrosine phosphorylation have been limited in scale and throughput due to the need for ...
Alexis T Chang +4 more
doaj +1 more source
Animals, 2021 In this study, we demonstrated that, in seasonal Mediterranean ovine breeds, supplementing the TALP medium with cAMP-elevating agents (the cocktail medium) is effective for achieving ram sperm capacitation, and that melatonin is able to regulate this ...
Melissa Carvajal-Serna +4 more
doaj +1 more source
Advanced Science, EarlyView.An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao +18 more
wiley +1 more source