Results 21 to 30 of about 40,216 (223)
Molecular & Cellular Oncology, 2020 We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in ...
Kristina B. Emdal, Alicia Lundby
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Ribonucleopeptides recognize the phosphotyrosine residue [PDF]
Nucleic Acids Symposium Series, 2005 Tools for selective recognition and sensing of kinase-catalyzed phosphorylation of Tyr or Ser/Thr residues located on a protein surface are essential for understanding signal transduction cascades of living cell. A stable complex of RNA and peptide (ribonucleopeptide) provides a new approach to tailor a receptor for small molecules.
Tetsuya, Hasegawa +2 more
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SH2 Domain Binding: Diverse FLVRs of Partnership
Frontiers in Endocrinology, 2020 The Src homology 2 (SH2) domain has a special role as one of the cornerstone examples of a “modular” domain. The interactions of this domain are very well-conserved, and have long been described as a bidentate, or “two-pronged plug” interaction between ...
Rachel Jaber Chehayeb +4 more
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Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria
Nature Chemical Biology, 2017 Tyrosine phosphorylation is a common protein posttranslational modification, which plays a critical role in signal transduction and the regulation of many cellular processes.
Xiaozhou Luo +19 more
semanticscholar +1 more source
Structure guided studies of the interaction between PTP1B and JAK
Communications Biology, 2023 Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates.
Rhiannon Morris +10 more
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A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function
Frontiers in Cell and Developmental Biology, 2021 The two homologous estrogen receptors ERα and ERβ exert distinct effects on their cognate tissues. Previous work from our laboratory identified an ERβ-specific phosphotyrosine residue that regulates ERβ transcriptional activity and antitumor function in ...
Bin Yuan +4 more
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Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain. [PDF]
PLoS ONE, 2010 The inhibition of specific SH2 domain mediated protein-protein interactions as an effective chemotherapeutic approach in the treatment of diseases remains a challenge. That different conformations of peptide-ligands are preferred by different SH2 domains
Joseph Nachman +5 more
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PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
Frontiers in Oncology, 2022 PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba +6 more
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Site-specific incorporation of phosphotyrosine using an expanded genetic code
Nature Chemical Biology, 2017 Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key for understanding the role of protein phosphorylation.
C. Hoppmann +6 more
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Communications Biology, 2022 Quantitative global phosphotyrosine proteomics of two mouse models of hypertrophic cardiomyopathy reveals that tyrosine kinase inhibitors may be a future therapeutic approach for treating hypertrophic cardiomyopathy.
Mingguo Xu +15 more
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