Results 11 to 20 of about 40,216 (223)
RSC Medicinal Chemistry, 2021 This review summarizes advances over the last decade in the design of phosphotyrosine and its phosphonate-based derivatives, focusing on their synthesis and medicinal chemistry applications.
Nikolai Makukhin, Alessio Ciulli
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Phosphotyrosine profiling of human cerebrospinal fluid
Clinical Proteomics, 2018 Background Cerebrospinal fluid (CSF) is an important source of potential biomarkers that affect the brain. Biomarkers for neurodegenerative disorders are needed to assist in diagnosis, monitoring disease progression and evaluating efficacy of therapies ...
Gajanan Sathe +6 more
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Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. [PDF]
PLoS ONE, 2014 The clinical outcome of Helicobacter pylori infections is determined by multiple host-pathogen interactions that may develop to chronic gastritis, and sometimes peptic ulcers or gastric cancer.
Judith Lind +6 more
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Earliest Holozoan Expansion of Phosphotyrosine Signaling [PDF]
Molecular Biology and Evolution, 2013 Phosphotyrosine (pTyr) signaling is involved in development and maintenance of metazoans' multicellular body through cell-to-cell communication. Tyrosine kinases (TKs), tyrosine phosphatases, and other proteins relaying the signal compose the cascade. Domain architectures of the pTyr signaling proteins are diverse in metazoans, reflecting their complex
Suga, Hiroshi +4 more
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A phosphotyrosine switch regulates organic cation transporters
Nature Communications, 2016 Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug ...
Jason A. Sprowl +23 more
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Multiple Functions of the Eya Phosphotyrosine Phosphatase [PDF]
Molecular and Cellular Biology, 2016 Eyes absent (Eya), a protein conserved from plants to humans and best characterized as a transcriptional coactivator, is also the prototype for a novel class of eukaryotic aspartyl protein tyrosine phosphatases. This minireview discusses recent breakthroughs in elucidating the substrates and cellular events regulated by Eya's tyrosine phosphatase ...
I. Rebay
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Phosphotyrosine proteomics reveals novel Zap70 and Itk pathway targets downstream of TCR and CAR in Jurkat T cells [PDF]
Scientific ReportsΖ-associated protein of 70 kDa (Zap70) and interleukin-2-inducible T cell kinase (Itk) propagate the primary and CD28-integrated phosphotyrosine (pY) signalling, respectively, to achieve full T cell activation.
Aurora Callahan +4 more
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A journey from phosphotyrosine to phosphohistidine and beyond
Molecules and Cells, 2022 Summary: Protein phosphorylation is a reversible post-translational modification. Nine out of the 20 natural amino acids in proteins can be phosphorylated, but most of what we know about the roles of protein phosphorylation has come from studies of ...
T. Hunter
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ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling [PDF]
Molecular OncologyTriple‐negative breast cancer (TNBC) is highly metastatic and presents clinical challenges given the lack of targeted therapies. Here, we report that the ShcD phosphotyrosine adaptor protein is upregulated in TNBC, and its expression correlates with ...
Hayley R. Lau +11 more
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eLife, 2021 SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer.
Vidyasiri Vemulapalli +14 more
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