Results 1 to 10 of about 418 (137)
Frontiers in Cell and Developmental Biology, 2023 Protein tyrosine phosphatases, together with protein tyrosine kinases, control many molecular signaling steps that control life at cellular and organismal levels. Impairing alterations in the genes encoding the involved proteins is expected to profoundly
Wiljan J. A. J. Hendriks +3 more
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IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins
Cells, 2023 The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple biological processes. The molecular mechanisms that underly spatial and temporal regulation of these interactions, which are crucial for proper cell functions, remain ...
Louise Thines +2 more
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A Lock on Phosphotyrosine Signaling [PDF]
ACS Chemical Biology, 2007 Protein phosphorylation plays a major role in cell signaling and human disease, so understanding the effects of tyrosine phosphorylation on protein structure and function is an area of intense investigation. A new technique allows site-specific incorporation of a non-hydrolyzable phosphotyrosine analogue into recombinant proteins, providing a new ...
Kathryn E, Muratore, Philip A, Cole
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A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics
eLife, 2021 Integrin adhesion complexes regulate cytoskeletal dynamics during cell migration. Adhesion activates phosphorylation of integrin-associated signaling proteins, including Cas (p130Cas, BCAR1), by Src-family kinases.
Elizabeth M Steenkiste +4 more
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Bioinformatics analysis reveals biophysical and evolutionary insights into the 3-nitrotyrosine post-translational modification in the human proteome [PDF]
Open Biology, 2013 Protein 3-nitrotyrosine is a post-translational modification that commonly arises from the nitration of tyrosine residues. This modification has been detected under a wide range of pathological conditions and has been shown to alter protein function ...
John Y. Ng +2 more
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Viruses, 2021 Hepatitis C virus (HCV) is the major causative pathogen associated with liver cirrhosis and hepatocellular carcinoma. The main virion component, the core (C) protein, has been implicated in several aspects of HCV pathology including oncogenesis and ...
Priya Devi +3 more
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The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. [PDF]
PLoS Pathogens, 2013 While phosphotyrosine modification is an established regulatory mechanism in eukaryotes, it is less well characterized in bacteria due to low prevalence. To gain insight into the extent and biological importance of tyrosine phosphorylation in Escherichia
Anne-Marie Hansen +14 more
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eLife, 2023 Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue.
Allyson Li +4 more
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Aptamer‐SH2 superbinder‐based targeted therapy for pancreatic ductal adenocarcinoma
Clinical and Translational Medicine, 2021 Background Pancreatic ductal adenocarcinoma (PDAC) exhibits the poorest prognosis of all solid tumors with a 5‐year survival rate of less than 10% and a median survival of 6 months after diagnosis.
An‐Dong Liu +7 more
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Journal for ImmunoTherapy of Cancer, 2021 BackgroundThe non-overlapping functions of the two estrogen receptor subtypes, ERα (Estrogen Receptor α)and ERβ (Estrogen Receptor β), in tumor cells have been studied extensively.
Jing Yang +9 more
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