Results 71 to 80 of about 40,216 (223)

Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1. [PDF]

PLoS ONE, 2015
Biofilms are important for cell communication and growth in most bacteria, and are responsible for a number of human clinical infections and diseases.
Kun Xu, Shanshan Li, Wen Yang, Kan Li, Yuwei Bai, Yueyang Xu, Jin Jin, Yingying Wang, Mark Bartlam   +8 more
doaj   +1 more source

Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs

Biomolecules, 2021
ErbBs are receptor tyrosine kinases involved not only in development, but also in a wide variety of diseases, particularly cancer. Their extracellular, transmembrane, juxtamembrane, and kinase folded domains were described extensively over the past 20 ...
Louise Pinet, Nadine Assrir, Carine van Heijenoort   +2 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Phosphotyrosine Mapping in Bcr/Abl Oncoprotein Using Phosphotyrosine-specific Immonium Ion Scanning

Molecular & Cellular Proteomics, 2003
Bcr/Abl is a fusion oncoprotein that is of paramount importance in chronic myelogenous leukemia and acute lymphocytic leukemia. The tyrosine-phosphorylated fraction of the p185 form of Bcr/Abl was isolated by immunoprecipitation with an anti-phosphotyrosine antibody and SDS-PAGE.
Steen, H., Fernandez, M., Ghaffari, S., Pandey, A., Mann, M.   +4 more
openaire   +3 more sources

Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1

Cell Reports, 2013
Adhesion between neurexin-1β (Nrx1β) and neuroligin-1 (Nlg1) induces early recruitment of the postsynaptic density protein 95 (PSD-95) scaffold; however, the associated signaling mechanisms are unknown.
Grégory Giannone, Magali Mondin, Dolors Grillo-Bosch, Béatrice Tessier, Edouard Saint-Michel, Katalin Czöndör, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine   +8 more
doaj   +1 more source

Inherent α‐Helix Around Tyrosine 183 in the Intrinsically Disordered Tail of the Multi‐Site Docking Platform Gab1

Biopolymers, Volume 117, Issue 5, September 2026.
The two phosphorylation sites within the Gab1 fragment 142‐203 exhibit distinct structural characteristics. Tyr162 is in a disordered region, Y183 in a helical segment. ABSTRACT The biological function of intrinsically disordered proteins is frequently coupled to short linear motifs, which serve as protein binding sites.
Anne Dietrich, Marc Lewitzky, Tobias Gruber, Jochen Balbach, Stephan M. Feller, Ulrich Weininger   +5 more
wiley   +1 more source

IL‐22Rα1 restrains pancreatic injury independently of its C‐terminal STAT3‐amplifying domain

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
IL‐22R, and to a lesser extent IL‐22, are key drivers of protection in acute pancreatitis. Although the C‐terminal domain of IL‐22R enhances STAT3 activation in the pancreas, it is not required for disease protection. Classical IL‐22R signaling alone is sufficient to control inflammation and promote pancreatic recovery.
Léna Puigdevall, Clara Stewardson, Lysa Dhulst, Emilie Hendrickx, Laure Dumoutier   +4 more
wiley   +1 more source

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

Cell, 2010
Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling -- tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains -- is a relatively new innovation.
W. Lim, T. Pawson
semanticscholar   +1 more source

Effect of propofol on the skeletal muscle insulin receptor in rats with hepatic ischemia-reperfusion injury

Journal of International Medical Research, 2020
Objective To investigate the effect of propofol on the expression and phosphorylation of the skeletal muscle insulin receptor and its substrates following hepatic ischemia-reperfusion injury (HIRI). Methods Sixty healthy Wistar rats were divided randomly
Zuping Chen, Li Zhang, Cunming Liu, Xuehao Wang, Chen Chen   +4 more
doaj   +1 more source

Specificity and regulation of phosphotyrosine signaling through SH2 domains

Journal of Structural Biology: X, 2020
Phosphotyrosine (pY) signaling is instrumental to numerous cellular processes. pY recognition occurs through specialized protein modules, among which the Src-homology 2 (SH2) domain is the most common.
Michelangelo Marasco, Teresa Carlomagno
doaj   +1 more source